The issue of co-morbid substance abuse and mental illness is clearly identified in the literature. The adequacy of the knowledge and skills of mental health professionals to deal with the complex problems associated with this co-morbidity has received considerable attention. The effect of an educational program on mental health professionals’ knowledge and perceptions of problematic alcohol and substance abuse was measured in a questionnaire survey in Victoria, Australia. The aim was to determine if an educational program could facilitate knowledge and attitudinal change among mental health professionals. In the pre-survey, a questionnaire on knowledge, skills, attitudes and practices was administered to 378 clinicians in Victoria (133 were returned, representing a 46%response rate). In the post-survey, 131 questionnaires were returned (response rate 35%). Significant changes in knowledge were reported following the educational program in the areas of overall knowledge of drug and alcohol, diagnosis of drug and alcohol abuse, and management of drug and alcohol abusers. While positive attitudes towards problematic drug and alcohol issues were expressed, specific educational programs to enhance their knowledge and skills in assessment and management of problematic drug and alcohol users are recommended.