Background: Renal disease has progressively affected Thai people. Protein diet has been well documented to induce renal hyper-filtration. Therefore, recommendation to patients with kidney disease should be clear. Egg white is indicated as complete protein. However, comparative study of its effect on renal function with protein of animal meat has been rarely reported. Objective: Evaluate renal response to egg white protein load as compared to chicken protein load. Material and Method: High protein loading from different sources was evaluated in 11 healthy volunteers. They were enrolled in two separate experiments conducted within 1-week interval. Baseline GFR was examined by 24 hour Ccr before each protein challenge. Then the subject randomly received a protein rich meal of 0.8 g/Kg.BW of steamed egg white or boiled chicken breast. The spot Ccr was performed every 60 minutes for 3 hours for finding peak GFR after high protein intake. Results: Baseline GFR of both experiments was not different. After two protein meals, GFR was significantly increased and reached the peak values at 60 minutes. There was no difference of peak GFR between both protein sources. The renal reserve was indicated as 64% and 58% increments from baseline values in egg white and chicken protein respectively. Conclusion: In normal subjects, egg white protein stimulated as high renal response as chicken protein when challenged with the same amount of protein.