| ชื่อเรื่อง | : | Dynamics and stability of polymorphic human telomeric G-quadruplex under tension |
| นักวิจัย | : | You, Huijuan , Zeng, Xiangjun , Xu, Yue , Lim, Ci Ji , Efremov, Artem K. , Phan, Anh Tuân , Yan, Jie |
| คำค้น | : | DRNTU::Science::Physics::Geophysics and geomagnetism |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2557 |
| อ้างอิง | : | You, H., Zeng, X., Xu, Y., Lim, C. J., Efremov, A. K., Phan, A. T., et al. (2014). Dynamics and stability of polymorphic human telomeric G-quadruplex under tension. Nucleic Acids Research, 42(13), 8789-8795. , 0305-1048 , http://hdl.handle.net/10220/20391 , http://dx.doi.org/10.1093/nar/gku581 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Nucleic acids research |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | As critical DNA structures capping the human chromosome ends, the stability and structural polymorphism of human telomeric G-quadruplex (G4) have drawn increasing attention in recent years. This work characterizes the equilibrium transitions of single-molecule telomeric G4 at physiological K+ concentration. We report three folded states of telomeric G4 with markedly different lifetime and mechanical stability. Our results show that the kinetically favored folding pathway is through a short-lived intermediate state to a longer-lived state. By examining the force dependence of transition rates, the force-dependent transition free energy landscape for this pathway is determined. In addition, an ultra-long-lived form of telomeric G4 structure with a much stronger mechanical stability is identified. |
| บรรณานุกรม | : |
You, Huijuan , Zeng, Xiangjun , Xu, Yue , Lim, Ci Ji , Efremov, Artem K. , Phan, Anh Tuân , Yan, Jie . (2557). Dynamics and stability of polymorphic human telomeric G-quadruplex under tension.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. You, Huijuan , Zeng, Xiangjun , Xu, Yue , Lim, Ci Ji , Efremov, Artem K. , Phan, Anh Tuân , Yan, Jie . 2557. "Dynamics and stability of polymorphic human telomeric G-quadruplex under tension".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. You, Huijuan , Zeng, Xiangjun , Xu, Yue , Lim, Ci Ji , Efremov, Artem K. , Phan, Anh Tuân , Yan, Jie . "Dynamics and stability of polymorphic human telomeric G-quadruplex under tension."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print. You, Huijuan , Zeng, Xiangjun , Xu, Yue , Lim, Ci Ji , Efremov, Artem K. , Phan, Anh Tuân , Yan, Jie . Dynamics and stability of polymorphic human telomeric G-quadruplex under tension. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.
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