| ชื่อเรื่อง | : | Engineering of interlocked DNA G-quadruplexes as a robust scaffold |
| นักวิจัย | : | Phan, Anh Tuân , Do, Ngoc Quang |
| คำค้น | : | DRNTU::Science::Medicine::Biomedical engineering. |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2555 |
| อ้างอิง | : | Phan, A. T., & Do, N. Q. (2013). Engineering of interlocked DNA G-quadruplexes as a robust scaffold. Nucleic Acids Research, 41(4), 2683-2688. , http://hdl.handle.net/10220/9982 , http://dx.doi.org/10.1093/nar/gks1304 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Nucleic acids research |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | Interlock is a structural element in DNA G-quadruplexes that can be compared with the commonly used complementary binding of ‘sticky ends’ in DNA duplexes. G-quadruplex interlocking can be a basis for the assembly of higher-order structures. In this study, we formulated a rule to engineer (3+1) interlocked dimeric G-quadruplexes and established the folding topology of the designed DNA sequences by nuclear magnetic resonance spectroscopy. These interlocked G-quadruplexes are very stable and can serve as compact robust scaffolds for various applications. Different structural elements can be engineered in these robust scaffolds. We demonstrated the anti-HIV inhibition activity of the newly designed DNA sequences. |
| บรรณานุกรม | : |
Phan, Anh Tuân , Do, Ngoc Quang . (2555). Engineering of interlocked DNA G-quadruplexes as a robust scaffold.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Phan, Anh Tuân , Do, Ngoc Quang . 2555. "Engineering of interlocked DNA G-quadruplexes as a robust scaffold".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Phan, Anh Tuân , Do, Ngoc Quang . "Engineering of interlocked DNA G-quadruplexes as a robust scaffold."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print. Phan, Anh Tuân , Do, Ngoc Quang . Engineering of interlocked DNA G-quadruplexes as a robust scaffold. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.
|
ridm@nrct.go.th ระบบคลังข้อมูลงานวิจัยไทย รายการโปรดที่คุณเลือกไว้
