| ชื่อเรื่อง | : | Discovery of a structural-element specific G-quadruplex “light-up” probe |
| นักวิจัย | : | Zhang, Liyun , Er, Jun Cheng , Ghosh, Krishna Kanta , Chung, Wan Jun , Yoo, Jaeduk , Xu, Wang , Zhao, Wei , Phan, Anh Tuân , Chang, Young-Tae |
| คำค้น | : | DRNTU::Science::Mathematics |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2557 |
| อ้างอิง | : | Zhang, L., Er, J. C., Ghosh, K. K., Chung, W. J., Yoo, J., Xu, W., et al. (2014). Discovery of a Structural-Element Specific G-Quadruplex “Light-Up” Probe. Scientific Reports, 4, 3776-. , 2045-2322 , http://hdl.handle.net/10220/18969 , http://dx.doi.org/10.1038/srep03776 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Scientific reports |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | The development of a fluorescent probe capable of detecting and distinguishing the wide diversity of G-quadruplex structures is particularly challenging. Herein, we report a novel BODIPY-based fluorescent sensor (GQR) that shows unprecedented selectivity to parallel-stranded G-quadruplexes with exposed ends and four medium grooves. Mechanistic studies suggest that GQR associates with G-quadruplex grooves close to the end of the tetrad core, which may explain the dye's specificity to only a subset of parallel structures. This specific recognition favours the disaggregation of GQR in aqueous solutions thereby recovering the inherent fluorescence of the dye. Due to its unique features, GQR represents a valuable tool for basic biological research and the rapid discovery of novel, specific ligands that target similar structural features of G-quadruplexes. |
| บรรณานุกรม | : |
Zhang, Liyun , Er, Jun Cheng , Ghosh, Krishna Kanta , Chung, Wan Jun , Yoo, Jaeduk , Xu, Wang , Zhao, Wei , Phan, Anh Tuân , Chang, Young-Tae . (2557). Discovery of a structural-element specific G-quadruplex “light-up” probe.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Zhang, Liyun , Er, Jun Cheng , Ghosh, Krishna Kanta , Chung, Wan Jun , Yoo, Jaeduk , Xu, Wang , Zhao, Wei , Phan, Anh Tuân , Chang, Young-Tae . 2557. "Discovery of a structural-element specific G-quadruplex “light-up” probe".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Zhang, Liyun , Er, Jun Cheng , Ghosh, Krishna Kanta , Chung, Wan Jun , Yoo, Jaeduk , Xu, Wang , Zhao, Wei , Phan, Anh Tuân , Chang, Young-Tae . "Discovery of a structural-element specific G-quadruplex “light-up” probe."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print. Zhang, Liyun , Er, Jun Cheng , Ghosh, Krishna Kanta , Chung, Wan Jun , Yoo, Jaeduk , Xu, Wang , Zhao, Wei , Phan, Anh Tuân , Chang, Young-Tae . Discovery of a structural-element specific G-quadruplex “light-up” probe. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.
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