| ชื่อเรื่อง | : | Monomer-dimer equilibrium for the 5′-5′ stacking of propeller-type parallel-stranded G-quadruplexes : NMR structural study |
| นักวิจัย | : | Do, Ngoc Quang , Phan, Anh Tuân |
| คำค้น | : | - |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2555 |
| อ้างอิง | : | Do, N. Q.,& Phan, A. T. (2012). Monomer-Dimer Equilibrium for the 5′-5′ Stacking of Propeller-Type Parallel-Stranded G-Quadruplexes: NMR Structural Study. Chemistry - A European Journal, 18(46), 14752-14759. , 0947-6539 , http://hdl.handle.net/10220/12935 , http://dx.doi.org/10.1002/chem.201103295 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Chemistry - a European journal |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | Guanine-rich sequence motifs, which contain tracts of three consecutive guanines connected by single non-guanine nucleotides, are abundant in the human genome and can form a robust G-quadruplex structure with high stability. Herein, by using NMR spectroscopy, we investigate the equilibrium between monomeric and 5′–5′ stacked dimeric propeller-type G-quadruplexes that are formed by DNA sequences containing GGGT motifs. We show that the monomer–dimer equilibrium depends on a number of parameters, including the DNA concentration, DNA flanking sequences, the concentration and type of cations, and the temperature. We report on the high-definition structure of a simple monomeric G-quadruplex containing three single-residue loops, which could serve as a reference for propeller-type G-quadruplex structures in solution. |
| บรรณานุกรม | : |
Do, Ngoc Quang , Phan, Anh Tuân . (2555). Monomer-dimer equilibrium for the 5′-5′ stacking of propeller-type parallel-stranded G-quadruplexes : NMR structural study.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Do, Ngoc Quang , Phan, Anh Tuân . 2555. "Monomer-dimer equilibrium for the 5′-5′ stacking of propeller-type parallel-stranded G-quadruplexes : NMR structural study".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Do, Ngoc Quang , Phan, Anh Tuân . "Monomer-dimer equilibrium for the 5′-5′ stacking of propeller-type parallel-stranded G-quadruplexes : NMR structural study."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print. Do, Ngoc Quang , Phan, Anh Tuân . Monomer-dimer equilibrium for the 5′-5′ stacking of propeller-type parallel-stranded G-quadruplexes : NMR structural study. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.
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