Thesis (M.Sc.)--Chulalongkorn University, 2012

This work focuses on the fabrication process of fragrance controlled release system that gives high fragrance concentration product with no need of preconcentration step. The process involves the fabrication of micron-sized fragrance spheres that combine two release mechanisms, the barrier of Schiff base chemical linkage between fragrant aldehyde or ketone and succinylchitosan and the physical polymer blend barrier. L-carvone and hexylcinnamaldehyde were used as a model fragrance. The process involves the synthesis of N-succinylchitosan through the reaction between chitosan and succinic anhydride. Then the obtained product was used in combination with ethylcellulose and methylcellulose to encapsulate fragrance by homogenization to obtain L-carvone-loaded micro-particles and hexylcinnamaldehyde-loaded micro-particles at 96.57±0.87 % and 81.43±0.67% (w/w) loading. The process gave 82.17±0.41% and 69.30±0.6% (w/w) encapsulation efficiency respectively. The release study under accelerated condition showed that this system could retain the fragranced ketones and aldehyde more effectively than the free ketone and free aldehyde.