The purpose of this research was to study factors associated with and probablycould predict burnout of registered nurses. These variables include personal factorsand job related factors. The samples consisted of 400 registered nurses in generalhospitals under the jurisdiction of the Ministry of Public Health, selected bymulti-stage sampling technique. The research instruments developed by theinvestigator, were questionnaires regarding social support from their family, jobrelated factors and burnout of registered nurses. The scale and questionnaires weretested for validity by panel experts. Alpha Cronbach reliability coefficients were.92 .80 and .92 respectively. The data were analyzed by using Chi-square test,Pearson's Product Moment Correlation and Stepwise Multiple Regression Analysis. The major findings were as follows : 1. Burnout of registered nurses in all aspects were at a low level except foremotional exhaustion which was at a moderate level. 2. Workload was positively correlated with burnout of registered nurses at the.05 level whereas social support from family, personal interrelationship in theworkplace, perception of management system and perception of professional competencywere negatively related to burnout of registered nurses, at the significant level of.05. 3. Workload, perception of professional competency, medical ward, personalinterrelationship in the workplace, and obstetric ward were the factors thatsignificantly predicted burnout of registered nurses at the level of .05. Thesepredictors accounted for 34.85 percent (R('2) = .3485) of the variance. The equation derived from the analysis are: Z = .4425 WORK -.2455 SELF + .1110 MED - .1100 INTER + .0891 OBSStandardized score of burnout = .4425 workload -.2455 perception of professionalcompetency + .1110 medical ward - .1100 personal interrelationsilip in the workplace+ .0891 obstetric ward.