"This work is aimed to develop the use of nanoparticles in the prevention and therapy of cancer. In the prevention of cancer, a synthetic receptor which could be able to bind with MDM2 protein was fabricated. Gold nanoparticles decorated with cationic-terminated ligand were synthesized. The cationic gold nanoparticles were bound with peptide and induced the alpha-helix structure of peptide. The formation of helical conformation were monitored using circular dichroism spectophotometer. The results showed that the helical structure was stable for 6 hours. This hybrid nanostructure were unstable in the presence of 15 mM of sodium chloride solution. This problem is required to be solved in order to use the hybrid material in biomedical application. The second approach of cancer therapy needed to be developed is the fabrication of nanoparticles. The results showed that stabilizers such as polyvinyl alcohol and sodium dodecyl sulphate play a crucial role in the formation of nanopartilces. These stabilizers also facilitated the release of drug which is essential in cancer therapy. This research has demonstrated that nanomaterials have a promising potential to be use in biomedical application."