In this thesis uniform asymptotic approximations of integrals are discussed. In order to derive these approximations, two well-known methods are used i.e., the saddle point method and the Bleistein method. To start with this, examples are given to demonstrate these two methods and a general idea of how to approach these techniques. The asymptotics of the hypergeometric functions with large parameters are discussed i.e., 2F1 (a + e1λ, b + e2λ c + e3λ ; z)where ej = 0,±1, j = 1, 2, 3 as |λ|→ ∞, which are valid in large regions of the complex z-plane, where a, b and c are fixed. The saddle point method is applied where the saddle point gives a dominant contributions to the integral representations of the hypergeometric functions and Bleistein’s method is adopted to obtain the uniform asymptotic approximations of some cases where the coalescence takes place between the critical points of the integrals. As a special case, the uniform asymptotic approximation of the hypergeometric function where the third parameter is large, is obtained. A new method to estimate the remainder term in the Bleistein method is proposed which is created to deal with new type of integrals in which the usual methods for the remainder estimates fail. Finally, using the asymptotic property of the hypergeometric function when the third parameter is large, the uniform asymptotic approximation of the monic Meixner Sobolev polynomials Sn(x) as n → ∞ , is obtained in terms of Airy functions. The asymptotic approximations for the location of the zeros of these polynomials are also discussed. As a limit case, a new asymptotic approximation for the large zeros of the classical Meixner polynomials is provided.