This research develops a theoretical framework explaining how University-Industry Linkages (UILs) affect the performance of tourism clusters in Thailand. Significant external and internal factors affecting Thai tourism industry are examined. The research questions are significant given the importance of successful tourism cluster through University-Industry Linkages (UIL). These questions recognized tourism clusters, the role of university, the linkages between university and industry, influential factors are contextual, and as a result, the author explores four tourism clusters in Thailand and using multiple case studies explains the nature and character of tourism cluster and University-Industry Linkages (UILs) between tourism cluster and its universities. The findings demonstrated that UILs, strategic entrepreneurship and leadership play key role to successful tourism cluster in developing countries.