| ชื่อเรื่อง | : | Semliki Forest virus strongly reduces mosquito host defence signaling |
| นักวิจัย | : | Fragkoudis, R , Siu, RW , Chi, Y , Barry, G , Attarzadeh-Yazdi, G , Nash, AA , Kohl, A , Fazakerley, JK , Merits, A |
| คำค้น | : | Arbovirus/Mosquito/Cell signalling |
| หน่วยงาน | : | Edinburgh Research Archive, United Kingdom |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2551 |
| อ้างอิง | : | Fragkoudis R, Chi Y, Siu RW, Barry G, Attarzadeh-Yazdi G, Merits A (external), Nash AA, Fazakerley JK, Kohl A. (2008-12-01) Semliki Forest virus strongly reduces mosquito host defence signaling, Insect Molecular Biology 17 (6) 647-656 , 0962-1075 , http://www3.interscience.wiley.com/journal/121415375/abstract , 10.1111/j.1365-2583.2008.00834.x , http://hdl.handle.net/1842/2991 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | - |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | The Alphavirus genus within the Togaviridae family contains several important mosquito-borne arboviruses. Other than the antiviral activity of RNAi, relatively little is known about alphavirus interactions with insect cell defences. Here we show that Semliki Forest virus (SFV) infection of Aedes albopictus-derived U4.4 mosquito cells reduces cellular gene expression. Activation prior to SFV infection of pathways involving STAT/IMD, but not Toll signaling reduced subsequent virus gene expression and RNA levels. These pathways are therefore not only able to mediate protective responses against bacteria but also arboviruses. However, SFV infection of mosquito cells did not result in activation of any of these pathways and suppressed their subsequent activation by other stimuli. |
| บรรณานุกรม | : |
Fragkoudis, R , Siu, RW , Chi, Y , Barry, G , Attarzadeh-Yazdi, G , Nash, AA , Kohl, A , Fazakerley, JK , Merits, A . (2551). Semliki Forest virus strongly reduces mosquito host defence signaling.
กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom . Fragkoudis, R , Siu, RW , Chi, Y , Barry, G , Attarzadeh-Yazdi, G , Nash, AA , Kohl, A , Fazakerley, JK , Merits, A . 2551. "Semliki Forest virus strongly reduces mosquito host defence signaling".
กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom . Fragkoudis, R , Siu, RW , Chi, Y , Barry, G , Attarzadeh-Yazdi, G , Nash, AA , Kohl, A , Fazakerley, JK , Merits, A . "Semliki Forest virus strongly reduces mosquito host defence signaling."
กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom , 2551. Print. Fragkoudis, R , Siu, RW , Chi, Y , Barry, G , Attarzadeh-Yazdi, G , Nash, AA , Kohl, A , Fazakerley, JK , Merits, A . Semliki Forest virus strongly reduces mosquito host defence signaling. กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom ; 2551.
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