| ชื่อเรื่อง | : | Cdk5 is essential for synaptic vesicle endocytosis |
| นักวิจัย | : | Tan, Timothy C , Valova, Valentina A , Malladi, Chandra S , Graham, Mark E , Berven, Leise A , Jupp, Orla J , Hansra, Gurdip , McClure, Sonya J , Sarcevic, Boris , Boadle, Ross A , Larsen, Martin R , Cousin, Michael A , Robinson, Phillip J |
| คำค้น | : | Synaptic vesicle endocytosis , cyclindependent kinase 5 |
| หน่วยงาน | : | Edinburgh Research Archive, United Kingdom |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2546 |
| อ้างอิง | : | Cdk5 is essential for synaptic vesicle endocytosis Tan TC, Valova VA, Malladi CS, Graham ME, Berven LA, Jupp OJ, Hansra G, McClure SJ, Sarcevic B, Boadle RA, Larsen MR, Cousin MA, Robinson PJ NATURE CELL BIOLOGY 5 (8): 701-710 AUG 2003 , doi:10.1038/ncb1020 , http://www.nature.com/ncb/ , http://hdl.handle.net/1842/758 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | - |
| ขอบเขตของเนื้อหา | : | 17 |
| บทคัดย่อ/คำอธิบาย | : | Synaptic vesicle endocytosis (SVE) is triggered by calcineurin-mediated dephosphorylation of the dephosphin proteins. SVE is maintained by the subsequent rephosphorylation of the dephosphins by unidentified protein kinases. Here, we show that cyclindependent kinase 5 (Cdk5) phosphorylates dynamin I on Ser 774 and Ser 778 in vitro, which are identical to its endogenous phosphorylation sites in vivo. Cdk5 antagonists and expression of dominant-negative Cdk5 block phosphorylation of dynamin I, but not of amphiphysin or AP180, in nerve terminals and inhibit SVE. Thus Cdk5 has an essential role in SVE and is the first dephosphin kinase identified in nerve terminals. |
| บรรณานุกรม | : |
Tan, Timothy C , Valova, Valentina A , Malladi, Chandra S , Graham, Mark E , Berven, Leise A , Jupp, Orla J , Hansra, Gurdip , McClure, Sonya J , Sarcevic, Boris , Boadle, Ross A , Larsen, Martin R , Cousin, Michael A , Robinson, Phillip J . (2546). Cdk5 is essential for synaptic vesicle endocytosis.
กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom . Tan, Timothy C , Valova, Valentina A , Malladi, Chandra S , Graham, Mark E , Berven, Leise A , Jupp, Orla J , Hansra, Gurdip , McClure, Sonya J , Sarcevic, Boris , Boadle, Ross A , Larsen, Martin R , Cousin, Michael A , Robinson, Phillip J . 2546. "Cdk5 is essential for synaptic vesicle endocytosis".
กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom . Tan, Timothy C , Valova, Valentina A , Malladi, Chandra S , Graham, Mark E , Berven, Leise A , Jupp, Orla J , Hansra, Gurdip , McClure, Sonya J , Sarcevic, Boris , Boadle, Ross A , Larsen, Martin R , Cousin, Michael A , Robinson, Phillip J . "Cdk5 is essential for synaptic vesicle endocytosis."
กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom , 2546. Print. Tan, Timothy C , Valova, Valentina A , Malladi, Chandra S , Graham, Mark E , Berven, Leise A , Jupp, Orla J , Hansra, Gurdip , McClure, Sonya J , Sarcevic, Boris , Boadle, Ross A , Larsen, Martin R , Cousin, Michael A , Robinson, Phillip J . Cdk5 is essential for synaptic vesicle endocytosis. กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom ; 2546.
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