| ชื่อเรื่อง | : | Musing on the structural organization of the exosome complex |
| นักวิจัย | : | Mitchell, Philip , Tollervey, David |
| คำค้น | : | structural , organisation , exosome , complex , RNA , degradation |
| หน่วยงาน | : | Edinburgh Research Archive, United Kingdom |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2543 |
| อ้างอิง | : | Mitchell P, Tollervey D, NATURE STRUCTURAL BIOLOGY, 7 (10): 843-846 OCT 2000 , http://structbio.nature.com , http://hdl.handle.net/1842/734 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | - |
| ขอบเขตของเนื้อหา | : | 4 |
| บทคัดย่อ/คำอธิบาย | : | The exosome complex of 3′→5′ exoribonucleases functions in both the precise processing of 3′ extended precursor molecules to mature stable RNAs and the complete degradation of other RNAs. Both processing and degradative activities of the exosome depend on additional cofactors, notably the putative RNA helicases Mtr4p and Ski2p. It is not known how these factors regulate exosome function or how the exosome distinguishes RNAs destined for processing events from substrates that are to be completely degraded. Here we review the available data concerning the modes of action of the exosome and relate these to possible structural arrangements for the complex. As no detailed structural data are yet available for the exosome complex, or any of its constituent enzymes, this discussion will rely heavily on rather speculative models. |
| บรรณานุกรม | : |
Mitchell, Philip , Tollervey, David . (2543). Musing on the structural organization of the exosome complex.
กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom . Mitchell, Philip , Tollervey, David . 2543. "Musing on the structural organization of the exosome complex".
กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom . Mitchell, Philip , Tollervey, David . "Musing on the structural organization of the exosome complex."
กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom , 2543. Print. Mitchell, Philip , Tollervey, David . Musing on the structural organization of the exosome complex. กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom ; 2543.
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