| ชื่อเรื่อง | : | Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene |
| นักวิจัย | : | Mack, Till GA , et al |
| คำค้น | : | Wallerian , degeneration , axons , synapses , Ube4b/Nmnat , chimeric gene |
| หน่วยงาน | : | Edinburgh Research Archive, United Kingdom |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2544 |
| อ้างอิง | : | Mack TGA et al, NATURE NEUROSCIENCE, 4 (12): 1199-1206 DEC 2001 , DOI: 10.1038/nn770 , http://neurosci.nature.com , http://hdl.handle.net/1842/737 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | - |
| ขอบเขตของเนื้อหา | : | 8 |
| บทคัดย่อ/คำอธิบาย | : | Axons and their synapses distal to an injury undergo rapid Wallerian degeneration, but axons in the C57BL/WldS mouse are protected. The degenerative and protective mechanisms are unknown. We identified the protective gene, which encodes an N-terminal fragment of ubiquitination factor E4B (Ube4b) fused to nicotinamide mononucleotide adenylyltransferase (Nmnat), and showed that it confers a dose-dependent block of Wallerian degeneration. Transected distal axons survived for two weeks, and neuromuscular junctions were also protected. Surprisingly, the Wld protein was located predominantly in the nucleus, indicating an indirect protective mechanism. Nmnat enzyme activity, but not NAD+ content, was increased fourfold in WldS tissues. Thus, axon protection is likely to be mediated by altered ubiquitination or pyridine nucleotide metabolism. |
| บรรณานุกรม | : |
Mack, Till GA , et al . (2544). Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene.
กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom . Mack, Till GA , et al . 2544. "Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene".
กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom . Mack, Till GA , et al . "Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene."
กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom , 2544. Print. Mack, Till GA , et al . Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene. กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom ; 2544.
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