| ชื่อเรื่อง | : | Ageing: Cognitive change and the APOEe4 allele |
| นักวิจัย | : | Deary, Ian J , Whiteman, Martha C , Pattie, Alison , Starr, John M , Hayward, Caroline , Wright, Alan F , Carothers, Andrew , Whalley, Lawrence J |
| คำค้น | : | Cognitive , apolipoprotein E , APOEe4 , allele , ageing , dementia , demented , Alzheimer’s disease |
| หน่วยงาน | : | Edinburgh Research Archive, United Kingdom |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2545 |
| อ้างอิง | : | Deary IJ, Whiteman MC, Pattie A, Starr JM, Hayward C, Wright AF, Carothers A, Whalley LJ, NATURE, 418 (6901): 932-932 AUG 29 2002 , http://www.nature.com/ , http://hdl.handle.net/1842/702 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | - |
| ขอบเขตของเนื้อหา | : | 2 |
| บทคัดย่อ/คำอธิบาย | : | There is a marked variation in whether people retain sufficient cognitive function to maintain their quality of life and independence in old age, even among those without dementia, so it would be valuable to identify the determinants of normal age-related cognitive change (1,2). We have retested non-demented 80-year-olds who were participants in the Scottish Mental Survey of 1932, and find that the variation in their non-pathological cognitive change from age 11 to 80 is related to their apolipoprotein E (APOE) genotype. This effect of the APOEe4 allele on normal cognitive ageing may be mediated by a mechanism that is at least partly independent of its predisposing effect towards Alzheimer’s disease. |
| บรรณานุกรม | : |
Deary, Ian J , Whiteman, Martha C , Pattie, Alison , Starr, John M , Hayward, Caroline , Wright, Alan F , Carothers, Andrew , Whalley, Lawrence J . (2545). Ageing: Cognitive change and the APOEe4 allele.
กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom . Deary, Ian J , Whiteman, Martha C , Pattie, Alison , Starr, John M , Hayward, Caroline , Wright, Alan F , Carothers, Andrew , Whalley, Lawrence J . 2545. "Ageing: Cognitive change and the APOEe4 allele".
กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom . Deary, Ian J , Whiteman, Martha C , Pattie, Alison , Starr, John M , Hayward, Caroline , Wright, Alan F , Carothers, Andrew , Whalley, Lawrence J . "Ageing: Cognitive change and the APOEe4 allele."
กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom , 2545. Print. Deary, Ian J , Whiteman, Martha C , Pattie, Alison , Starr, John M , Hayward, Caroline , Wright, Alan F , Carothers, Andrew , Whalley, Lawrence J . Ageing: Cognitive change and the APOEe4 allele. กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom ; 2545.
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