| ชื่อเรื่อง | : | Oxo-iron clusters in a bacterial iron-trafficking protein: new roles for a conserved motif |
| นักวิจัย | : | Zhu, Haizhong , Alexeev, Dmitriy , Hunter, Dominic JB , Campopiano, Dominic J , Sadler, Peter J |
| คำค้น | : | Bacterial Transferrin , Dityrosyl motif , iron-binding protein , iron transport , oxo-iron cluster , x-ray crystallography |
| หน่วยงาน | : | Edinburgh Research Archive, United Kingdom |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2546 |
| อ้างอิง | : | Biochemical Journal (2003), 376(1), 35-41 , http://hdl.handle.net/1842/661 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | - |
| ขอบเขตของเนื้อหา | : | 7 |
| บทคัดย่อ/คำอธิบาย | : | We report a set of three 1.8–1.9 Å resolution X-ray crystal structures of Neisseria gonorrhoeae Fbp (ferric-ion binding protein): (i) open-cleft apo-Fbp containing bound phosphate, (ii) opencleft mono-Fe Fbp capped by nitrilotriacetate, and (iii) open-cleft trinuclear oxo-iron Fbp, the first structure of an iron-cluster adduct of a transferrin. The nine independent molecules in the unit cells provide ‘snapshots’ of the versatile dynamic structural roles of the conserved dityrosyl iron-binding motif (Tyr195-Tyr196) which control the capture and, possibly, processing of iron. These findings have implications for understanding bacterial iron acquisition and dissimilation, and organic/mineral interfaces. Key words: bacterial transferrin, dityrosyl motif, iron-binding protein, iron transport, oxo-iron cluster, X-ray crystallography. |
| บรรณานุกรม | : |
Zhu, Haizhong , Alexeev, Dmitriy , Hunter, Dominic JB , Campopiano, Dominic J , Sadler, Peter J . (2546). Oxo-iron clusters in a bacterial iron-trafficking protein: new roles for a conserved motif.
กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom . Zhu, Haizhong , Alexeev, Dmitriy , Hunter, Dominic JB , Campopiano, Dominic J , Sadler, Peter J . 2546. "Oxo-iron clusters in a bacterial iron-trafficking protein: new roles for a conserved motif".
กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom . Zhu, Haizhong , Alexeev, Dmitriy , Hunter, Dominic JB , Campopiano, Dominic J , Sadler, Peter J . "Oxo-iron clusters in a bacterial iron-trafficking protein: new roles for a conserved motif."
กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom , 2546. Print. Zhu, Haizhong , Alexeev, Dmitriy , Hunter, Dominic JB , Campopiano, Dominic J , Sadler, Peter J . Oxo-iron clusters in a bacterial iron-trafficking protein: new roles for a conserved motif. กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom ; 2546.
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