| ชื่อเรื่อง | : | Enhanced CpG Mutability and Tumorigenesis in MBD4-Deficient Mice |
| นักวิจัย | : | Millar, Catherine B , Guy, Jacky , Sansom, Owen J , Selfridge, Jim , MacDougall, Eilidh , Hendrich, Brian , Keightley, Peter D , Bishop, Stefan M , Clarke, Alan R , Bird, Adrian P |
| คำค้น | : | - |
| หน่วยงาน | : | Edinburgh Research Archive, United Kingdom |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2545 |
| อ้างอิง | : | Science, Vol 297, Issue 5580, 403-405 , 19 July 2002 , 0036-8075 , http://www.sciencemag.org/cgi/content/full/297/5580/403 , [DOI: 10.1126/science.1073354] , http://hdl.handle.net/1842/462 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | - |
| ขอบเขตของเนื้อหา | : | 3 |
| บทคัดย่อ/คำอธิบาย | : | The mammalian protein MBD4 contains a methyl-CpG binding domain and can enzymatically remove thymine (T) or uracil (U) from a mismatched CpG site in vitro. These properties suggest that MBD4 might function in vivo to minimize the mutability of 5-methylcytosine by removing its deamination product from DNA. We tested this hypothesis by analyzing Mbd4(-/-) mice and found that the frequency of of C 3 T transitions at CpG sites was increased by a factor of three. On a cancer-susceptible Apc(Min/+) background, Mbd4(-/-) mice showed accelerated tumor formation with CpG --> TpG mutations in the Apc gene. Thus MBD4 suppresses CpG mutability and tumorigenesis in vivo. |
| บรรณานุกรม | : |
Millar, Catherine B , Guy, Jacky , Sansom, Owen J , Selfridge, Jim , MacDougall, Eilidh , Hendrich, Brian , Keightley, Peter D , Bishop, Stefan M , Clarke, Alan R , Bird, Adrian P . (2545). Enhanced CpG Mutability and Tumorigenesis in MBD4-Deficient Mice.
กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom . Millar, Catherine B , Guy, Jacky , Sansom, Owen J , Selfridge, Jim , MacDougall, Eilidh , Hendrich, Brian , Keightley, Peter D , Bishop, Stefan M , Clarke, Alan R , Bird, Adrian P . 2545. "Enhanced CpG Mutability and Tumorigenesis in MBD4-Deficient Mice".
กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom . Millar, Catherine B , Guy, Jacky , Sansom, Owen J , Selfridge, Jim , MacDougall, Eilidh , Hendrich, Brian , Keightley, Peter D , Bishop, Stefan M , Clarke, Alan R , Bird, Adrian P . "Enhanced CpG Mutability and Tumorigenesis in MBD4-Deficient Mice."
กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom , 2545. Print. Millar, Catherine B , Guy, Jacky , Sansom, Owen J , Selfridge, Jim , MacDougall, Eilidh , Hendrich, Brian , Keightley, Peter D , Bishop, Stefan M , Clarke, Alan R , Bird, Adrian P . Enhanced CpG Mutability and Tumorigenesis in MBD4-Deficient Mice. กรุงเทพมหานคร : Edinburgh Research Archive, United Kingdom ; 2545.
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