| ชื่อเรื่อง | : | Metal-Free Tandem Approach to Structurally Diverse N-Heterocycles: Synthesis of 1,2,4-Oxadiazoles and Pyrimidinones |
| นักวิจัย | : | Gupta, P K , Hussain, M K , Asad, Mohd. , Kant, Ruchir , Mahar, Rohit , Shukla, S K , Hajela, Kanchan |
| คำค้น | : | N-Heterocycles , Oxadiazoles , Pyrimidinones |
| หน่วยงาน | : | Central Drug Research Institute (CDRI), India |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2557 |
| อ้างอิง | : | New Journal of Chemistry, 2014, 38(7) 3062-3070 , http://hdl.handle.net/123456789/1366 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | CSIR-CDRI Communication No. 8671 |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | A metal-free one-pot approach to the diversity oriented synthesis of N-heterocycles, 1,2,4-oxadiazoles and 2,6 disubstituted pyrimidin-4-ones is described via carboxamidation of amidines with aryl carboxylic acids and aryl propargylic acids. The reactions occur at room temperature forming N-acylamidines which undergo tandem nucleophilic addition / deamination / intramolecular cyclisation to give the corresponding heterocyclic compounds in good to excellent yields. This one pot approach has led to the successful synthesis of drug lead molecule, ataluren, (3-(5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl) benzoic acid in two steps. |
| บรรณานุกรม | : |
Gupta, P K , Hussain, M K , Asad, Mohd. , Kant, Ruchir , Mahar, Rohit , Shukla, S K , Hajela, Kanchan . (2557). Metal-Free Tandem Approach to Structurally Diverse N-Heterocycles: Synthesis of 1,2,4-Oxadiazoles and Pyrimidinones.
: Central Drug Research Institute (CDRI), India. Gupta, P K , Hussain, M K , Asad, Mohd. , Kant, Ruchir , Mahar, Rohit , Shukla, S K , Hajela, Kanchan . 2557. "Metal-Free Tandem Approach to Structurally Diverse N-Heterocycles: Synthesis of 1,2,4-Oxadiazoles and Pyrimidinones".
: Central Drug Research Institute (CDRI), India. Gupta, P K , Hussain, M K , Asad, Mohd. , Kant, Ruchir , Mahar, Rohit , Shukla, S K , Hajela, Kanchan . "Metal-Free Tandem Approach to Structurally Diverse N-Heterocycles: Synthesis of 1,2,4-Oxadiazoles and Pyrimidinones."
: Central Drug Research Institute (CDRI), India, 2557. Print. Gupta, P K , Hussain, M K , Asad, Mohd. , Kant, Ruchir , Mahar, Rohit , Shukla, S K , Hajela, Kanchan . Metal-Free Tandem Approach to Structurally Diverse N-Heterocycles: Synthesis of 1,2,4-Oxadiazoles and Pyrimidinones. : Central Drug Research Institute (CDRI), India; 2557.
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