| ชื่อเรื่อง | : | A neuroprotective role for microRNA miR-1000 mediated by limiting glutamate excitotoxicity |
| นักวิจัย | : | Verma, Pushpa , Augustine, George J , Ammar, Mohamed-Raafet , Tashiro, Ayumu , Cohen, Stephen M |
| คำค้น | : | DRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiology |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2558 |
| อ้างอิง | : | Verma, P., Augustine, G. J., Ammar, M.-R., Tashiro, A., & Cohen, S. M. (2015). A neuroprotective role for microRNA miR-1000 mediated by limiting glutamate excitotoxicity. Nature neuroscience, 18(3), 379-385. , http://hdl.handle.net/10220/25258 , http://dx.doi.org/10.1038/nn.3935 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Nature neuroscience |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | Evidence has begun to emerge for microRNAs as regulators of synaptic signaling, specifically acting to control postsynaptic responsiveness during synaptic transmission. In this report, we provide evidence that Drosophila melanogaster miR-1000 acts presynaptically to regulate glutamate release at the synapse by controlling expression of the vesicular glutamate transporter (VGlut). Genetic deletion of miR-1000 led to elevated apoptosis in the brain as a result of glutamatergic excitotoxicity. The seed-similar miR-137 regulated VGluT2 expression in mouse neurons. These conserved miRNAs share a neuroprotective function in the brains of flies and mice. Drosophila miR-1000 showed activity-dependent expression, which might serve as a mechanism to allow neuronal activity to fine-tune the strength of excitatory synaptic transmission. |
| บรรณานุกรม | : |
Verma, Pushpa , Augustine, George J , Ammar, Mohamed-Raafet , Tashiro, Ayumu , Cohen, Stephen M . (2558). A neuroprotective role for microRNA miR-1000 mediated by limiting glutamate excitotoxicity.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Verma, Pushpa , Augustine, George J , Ammar, Mohamed-Raafet , Tashiro, Ayumu , Cohen, Stephen M . 2558. "A neuroprotective role for microRNA miR-1000 mediated by limiting glutamate excitotoxicity".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Verma, Pushpa , Augustine, George J , Ammar, Mohamed-Raafet , Tashiro, Ayumu , Cohen, Stephen M . "A neuroprotective role for microRNA miR-1000 mediated by limiting glutamate excitotoxicity."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2558. Print. Verma, Pushpa , Augustine, George J , Ammar, Mohamed-Raafet , Tashiro, Ayumu , Cohen, Stephen M . A neuroprotective role for microRNA miR-1000 mediated by limiting glutamate excitotoxicity. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2558.
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