The causal relationships of organizational culture with organizational structure and with the implementation of knowledge management are quite complicated. No prior studies have explored these causal relationships in a joint model. Grounded on the concepts of prior research, this research applies path analysis to simultaneously investigate the causal relationships in a proposed joint research model. It also examines how organizational structure intervenes with the causal relationship between organizational culture and the implementation of knowledge management. The findings report that organizational culture makes statistically significant influences on organizational structure and the implementation of knowledge management that is statistically explained by organizational structure. The effect of the organizational culture on implementation of knowledge management is statistically mediated by organizational structure. This research has some implications on how business managers should adopt knowledge management facing different types of organizational culture and organizational structure.