This paper develops a power loss optimization method in a current fed zero-voltage switching (ZVS) two-inductor boost converter, which is suitable for the module integrated converter applications in grid interactive photovoltaic systems. The paper conducts the numerical analysis of the variable power loss components and establishes a set of the circuit parameters for an optimized operating point with a minimized average power loss. The ZVS twoinductor boost cell is fed from a sinusoidally modulated two-phase synchronous buck converter with an interphase transformer and produces a rectified sinusoidal voltage, which can be applied to an unfolding stage to generate the grid compatible voltage. The boost cell is also equipped with a resonant transition gate drive circuit to reduce the power loss in the drive circuit under high frequency operations. The experimental results for a prototype 1-MHz 100-W ZVS two-inductor boost converter are presented at the end of the paper.