This paper is concerned with active packet dropouts-based anti-disturbance performance optimization for a continuous-time networked control system (NCS) under consideration of time-varying network-induced delays. By proposing the active packet dropouts method, a new model for an NCS is established. Based on the established model, stabilizing controller design criteria are derived to optimize the anti-disturbance performance of the considered NCS. When transferring nonlinear matrix inequalities into linear matrix inequalities, a parameter searching algorithm and new bounding inequalities are proposed to introduce less conservatism. The mutually exclusive distribution characteristic of the interval time-varying delays is made full use to deal with integral inequalities for products of vectors. A numerical example is given to illustrate the effectiveness of the proposed active packet dropouts-based anti-disturbance performance optimization.