This chapter explores the pathophysiology, manifestations, complications, interdisciplinary care and nursing care of disorders of female sexual function, menstrual disorders, structural disorders, reproductive tissue disorders and breast disorders. The physiological process of menopause is explained and the incidence, risk factors, pathophysiology, manifestations, diagnosis, treatment and nursing care for cancer of the cervix, endometrium, ovary, vulva and breast are examined. In addition the purposes, nursing implications and health education for clients and their families for cancer screening, medications and treatments for women with disorders of the reproductive system and breast are discussed along with alternative and complementary therapies used by women to relieve manifestations associated with menopause and menstrual disorders. The chapter concludes with a discussion of surgical procedures used to treat female reproductive system and breast disorders.