| ชื่อเรื่อง | : | A fast algorithm for BayesB type of prediction of genome-wide estimates of genetic value |
| นักวิจัย | : | Meuwissen, Theo H. E. , Solberg, Trygve R. , Shepherd, Ross K. , Woolliams, John A. |
| คำค้น | : | Genomics. , Applied research. , 839999 Animal Production and Animal Primary Products not elsewhere classified. , 070201 Animal Breeding. , 060412 Quantitative Genetics (incl. Disease and Trait Mapping Genetics) , 010401 Applied Statistics. , Genetic markers. , Genomic selection -- SNP markers -- Genomic breeding value -- BLUP -- Bayesian |
| หน่วยงาน | : | Central Queensland University, Australia |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2552 |
| อ้างอิง | : | http://hdl.cqu.edu.au/10018/43238 , http://www.gsejournal.org/content/41/1/2 |
| ที่มา | : | Meuwissen, T, Solberg, T, Shepherd, R & Woolliams, J 2009, 'A fast algorithm for BayesB type of prediction of genome-wide estimates of genetic value', Genetics Selection Evolution , vol. 41, no. 2, pp. 1-10.http://dx.doi.org/10.1186/1297-9686-41-2 (viewed 15/4/10) |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Genetics selection evolution. United Kingdom. : BioMed Central Ltd, 2009. Vol. 41, no. 2 (2009), p. 1-10 10 pages Refereed 1297-9686 , ACQUIRE [electronic resource] : Central Queensland University Institutional Repository. |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | Genomic selection uses genome-wide dense SNP marker genotyping for the prediction of genetic values, and consists of two steps: (1) estimation of SNP effects, and (2) prediction of genetic value based on SNP genotypes and estimates of their effects. For the former step, BayesB type of estimators have been proposed, which assume a priori that many markers have no effects, and some have an effect coming from a gamma or exponential distribution, i.e. a fat-tailed distribution. Whilst such estimators have been developed using Monte Carlo Markov chain (MCMC), here we derive a much faster non-MCMC based estimator by analytically performing the required integrations. The accuracy of the genome-wide breeding value estimates was 0.011 (s.e. 0.005) lower than that of the MCMC based BayesB predictor, which may be because the integrations were performed one-by-one instead of for all SNPs simultaneously. The bias of the new method was opposite to that of the MCMC based BayesB, in that the new method underestimates the breeding values of the best selection candidates, whereas MCMC-BayesB overestimated their breeding values. The new method was computationally several orders of magnitude faster than MCMC based BayesB, which will mainly be advantageous in computer simulations of entire breeding schemes, in cross-validation testing, and practical schemes with frequent re-estimation of breeding values. |
| บรรณานุกรม | : |
Meuwissen, Theo H. E. , Solberg, Trygve R. , Shepherd, Ross K. , Woolliams, John A. . (2552). A fast algorithm for BayesB type of prediction of genome-wide estimates of genetic value.
กรุงเทพมหานคร : Central Queensland University, Australia. Meuwissen, Theo H. E. , Solberg, Trygve R. , Shepherd, Ross K. , Woolliams, John A. . 2552. "A fast algorithm for BayesB type of prediction of genome-wide estimates of genetic value".
กรุงเทพมหานคร : Central Queensland University, Australia. Meuwissen, Theo H. E. , Solberg, Trygve R. , Shepherd, Ross K. , Woolliams, John A. . "A fast algorithm for BayesB type of prediction of genome-wide estimates of genetic value."
กรุงเทพมหานคร : Central Queensland University, Australia, 2552. Print. Meuwissen, Theo H. E. , Solberg, Trygve R. , Shepherd, Ross K. , Woolliams, John A. . A fast algorithm for BayesB type of prediction of genome-wide estimates of genetic value. กรุงเทพมหานคร : Central Queensland University, Australia; 2552.
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