| ชื่อเรื่อง | : | The integrin αL leg region controls the Mg/EGTA mediated activation of LFA-1 |
| นักวิจัย | : | Guan, Siyu , Cheng, Ming , Law, S.K. Alex |
| คำค้น | : | DRNTU::Science::Biological sciences::Biophysics |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2558 |
| อ้างอิง | : | Guan, S., Cheng, M., & Law, S. K. A. (2015). The integrin αL leg region controls the Mg/EGTA mediated activation of LFA-1. Biochemical and biophysical research communications, 458(2), 251-255. , 0006-291X , http://hdl.handle.net/10220/25193 , http://dx.doi.org/10.1016/j.bbrc.2015.01.094 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Biochemical and biophysical research communications |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | We have shown that Mg/EGTA (5 mM Mg(2+) and 1.5 mM EGTA) could effectively promote the adhesion of integrin αLβ2 to its ligand ICAM-1 but could not promote that of the αMβ2 to denatured BSA. In order to determine the structural differences between αL and αM that specifically contribute to Mg/EGTA sensitivity, a series of αL/αM chimeras were constructed. Our results showed that αLβ2 with αM calf-1 domain completely lost the response to Mg/EGTA activation. In the reverse experiment, αMβ2 would require the presence of both the αL calf-1 and calf-2 domain to initiate the Mg/EGTA sensitivity. |
| บรรณานุกรม | : |
Guan, Siyu , Cheng, Ming , Law, S.K. Alex . (2558). The integrin αL leg region controls the Mg/EGTA mediated activation of LFA-1.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Guan, Siyu , Cheng, Ming , Law, S.K. Alex . 2558. "The integrin αL leg region controls the Mg/EGTA mediated activation of LFA-1".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Guan, Siyu , Cheng, Ming , Law, S.K. Alex . "The integrin αL leg region controls the Mg/EGTA mediated activation of LFA-1."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2558. Print. Guan, Siyu , Cheng, Ming , Law, S.K. Alex . The integrin αL leg region controls the Mg/EGTA mediated activation of LFA-1. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2558.
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