The potential use of photoinitiated polymerization in the development of acrylic based resin for bone replacement was studied. Two types of photoinitiators, H-Nu-blue 640 and Irgacure 261, suitable to the photopolymerization under irradiation with red light, have been used in this study. The effect of the amounts of initiators, variously combined with their co-initiators, on curing efficiency was investigated using Fourier Transform Infrared Spectroscopy (FTIR). Irgacure 261 seemed to be the appropriate photoinitiating system compared to H-Nu-blue 640 since it yielded the cured resin with the higher degree of conversion. The influence of the resin composition on mechanical properties was also investigated. The acrylic resins, consisted of various types of monomer including bis-phenol A glycidyl dimethacrylate (bis-GMA), triethylene glycol dimethacrylate (TEGDMA) and methyl methacrylate (MMA), were formulated and photopolymerized. Three-point bending and compressive tests were performed using Universal Testing Machine, to assess the mechanical properties of each resin formulation. The mechanical properties were found dependent on the degree of conversion and the resin composition. The results showed that it was possible to cure acrylic resin under red light to obtain the cured resin with comparable mechanical properties to the commercially medical poly (methyl methacrylate) (PMMA).