Due to rapid economic and population growth in Thailand after 1990, increasing number of vehicles has contributed to high energy consumption and CO2 emission in the transport sector. The road transport is the main land transport mode in Thailand, and it is responsible for about 77.0% of energy consumption in the transport sector during the past two decades. Therefore, the objectives of this study are to examine the historical growth and patterns of energy consumption in the road transport during 2005-2010 in order to estimate the transport demand and CO2 emissions in 2030. Moreover, this study considers CO2 emission from three fuel types: oil, gas and electricity. This study employs the end-use model called "Long-range Energy Alternative Planning" (LEAP) model developed by Stockholm Environment Institute (SEI) for tracking energy consumption. The measures in the transport sector include: i) transport modal shift, ii) fuel switching, and iii) advanced technologies. The modal shift in passenger transport is composed of: i) replacing sedans by buses, ii) non-motorized implementation, and iii) walking. The fuel switching action is aimed at utilization of alternative energy resources, which include: i) high speed diesel blended with bio-oil named B5, ii) B10, and iii) B20 respectively, and iv) gasoline blended with ethanol 10%, 20%, 85% named E10, E20 and E85, respectively. The advanced technologies are: i) hybrid vehicles, ii) plug-in hybrid vehicles, and iii) electric vehicles. Results of analyses show that energy consumption in the road transport will increase from 19,327 ktoe in 2010 to 37,587 ktoe in 2030. The corresponding CO2 emissions will increase from 44,945 kt-CO2 in 2010 to 84,922 kt-CO2 in 2030.