The human head is one of the most sensitive parts of the human entire body when exposed to electromagnetic radiation. This electromagnetic radiation interacts with the human head and may lead to detrimental effects on human health. However, the resulting thermophysiologic response of the human head is not well understood. In order to gain insight into the phenomena occurring within the human head with temperature distribution induced by electromagnetic field, a detailed knowledge of absorbed power distribution as well as temperature distribution is necessary. This study presents a numerical analysis of specific absorption rate and heat transfer in the heterogeneous human head model exposed to mobile phone radiation. In the heterogeneous human head model, the effects of user age and radiated power on distributions of specific absorption rate and temperature profile within the human head are systematically investigated. This study focuses attention on organs in the human head in order to investigate the effects of mobile phone radiation on the human head. The specific absorption rate and the temperature distribution obtained by numerical solution of electromagnetic wave propagation and unsteady bioheat transfer equation in various tissues in the human head during exposure to mobile phone radiation are presented. © 2012 American Society of Mechanical Engineers. © 2012 VC by ASME.