| ชื่อเรื่อง | : | Association between HLA-B*1502 and carbamazepine-induced severe cutaneous adverse drug reactions in a Thai population |
| นักวิจัย | : | Wichittra Tassaneeyakul , Somsak Tiamkao , Thawinee Jantararoungtong , Chen, Pei , Lin, Shu-Yi , Chen, Wei-Hsuan , Parinya Konyoung , Usanee Khunarkornsiri , Narong Auvichayapat , Kasemsin Pavakul , Kongkiat Kulkantrakorn , Charoen Choonhakarn , Siranun Phonhiamhan , Namfon Piyatrakul , Thiti Aungaree , Sunsanee Pongpakdee , Praphan Yodnopaglaw |
| คำค้น | : | Carbamazepine , HLA-B*1502 , Severe cutaneous adverse drug reactions , Stevens-Johnson syndrome (SJS) , Toxic epidermal necrolysis (TEN) , Thailand |
| หน่วยงาน | : | สถาบันวิจัยและให้คำปรึกษาแห่ง มหาวิทยาลัยธรรมศาสตร์ |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2553 |
| อ้างอิง | : | Epilepsia. 51,5 (2010) pp. 926-930 , 0013-9580 , http://dspace.library.tu.ac.th/handle/3517/4651 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | - |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | Carbamazepine (CBZ) has been reported as the most common culprit drug for Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in several Asian countries including Thailand. A strong association between HLA-B*1502 and CBZ-induced SJS/TEN has been reported in Han Chinese but not in Caucasian and Japanese populations. A case-control study was conducted to determine whether HLA-B*1502 is a valid pharmacogenetic test for SJS/TEN caused by CBZ in a Thai population. Among 42 CBZ-induced patients with SJS/TEN, 37 (88.10%) patients carried the HLA-B*1502 while only 5 (11.90%) of the CBZ-tolerant controls had this allele. The risk of CBZ-induced SJS/TEN was significantly higher in the patients with HLA-B*1502, with an odds ratio (OR) of 54.76 [95% confidence interval (CI) 14.62-205.13, p = 2.89 × 10-12]. The sensitivity and specificity of HLA-B*1502 for prediction of CBZ-induced SJS/TEN were 88.10%. By assuming a 0.27% as a prevalence rate of CBZ-induced SJS/TEN in a Thai population, the positive predictive value (PPV) and negative predictive value (NPV) of the HLA-B*1502 were 1.92% and 99.96%. Results from this study suggest that HLA-B*1502 may be a useful pharmacogenetic test for screening Thai individuals who may be at risk for CBZ-induced SJS and TEN. © 2010 International League Against Epilepsy. |
| บรรณานุกรม | : |
Wichittra Tassaneeyakul , Somsak Tiamkao , Thawinee Jantararoungtong , Chen, Pei , Lin, Shu-Yi , Chen, Wei-Hsuan , Parinya Konyoung , Usanee Khunarkornsiri , Narong Auvichayapat , Kasemsin Pavakul , Kongkiat Kulkantrakorn , Charoen Choonhakarn , Siranun Phonhiamhan , Namfon Piyatrakul , Thiti Aungaree , Sunsanee Pongpakdee , Praphan Yodnopaglaw . (2553). Association between HLA-B*1502 and carbamazepine-induced severe cutaneous adverse drug reactions in a Thai population.
กรุงเทพมหานคร : สถาบันวิจัยและให้คำปรึกษาแห่ง มหาวิทยาลัยธรรมศาสตร์ . Wichittra Tassaneeyakul , Somsak Tiamkao , Thawinee Jantararoungtong , Chen, Pei , Lin, Shu-Yi , Chen, Wei-Hsuan , Parinya Konyoung , Usanee Khunarkornsiri , Narong Auvichayapat , Kasemsin Pavakul , Kongkiat Kulkantrakorn , Charoen Choonhakarn , Siranun Phonhiamhan , Namfon Piyatrakul , Thiti Aungaree , Sunsanee Pongpakdee , Praphan Yodnopaglaw . 2553. "Association between HLA-B*1502 and carbamazepine-induced severe cutaneous adverse drug reactions in a Thai population".
กรุงเทพมหานคร : สถาบันวิจัยและให้คำปรึกษาแห่ง มหาวิทยาลัยธรรมศาสตร์ . Wichittra Tassaneeyakul , Somsak Tiamkao , Thawinee Jantararoungtong , Chen, Pei , Lin, Shu-Yi , Chen, Wei-Hsuan , Parinya Konyoung , Usanee Khunarkornsiri , Narong Auvichayapat , Kasemsin Pavakul , Kongkiat Kulkantrakorn , Charoen Choonhakarn , Siranun Phonhiamhan , Namfon Piyatrakul , Thiti Aungaree , Sunsanee Pongpakdee , Praphan Yodnopaglaw . "Association between HLA-B*1502 and carbamazepine-induced severe cutaneous adverse drug reactions in a Thai population."
กรุงเทพมหานคร : สถาบันวิจัยและให้คำปรึกษาแห่ง มหาวิทยาลัยธรรมศาสตร์ , 2553. Print. Wichittra Tassaneeyakul , Somsak Tiamkao , Thawinee Jantararoungtong , Chen, Pei , Lin, Shu-Yi , Chen, Wei-Hsuan , Parinya Konyoung , Usanee Khunarkornsiri , Narong Auvichayapat , Kasemsin Pavakul , Kongkiat Kulkantrakorn , Charoen Choonhakarn , Siranun Phonhiamhan , Namfon Piyatrakul , Thiti Aungaree , Sunsanee Pongpakdee , Praphan Yodnopaglaw . Association between HLA-B*1502 and carbamazepine-induced severe cutaneous adverse drug reactions in a Thai population. กรุงเทพมหานคร : สถาบันวิจัยและให้คำปรึกษาแห่ง มหาวิทยาลัยธรรมศาสตร์ ; 2553.
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