| ชื่อเรื่อง | : | A preloaded amorphous calcium carbonate/doxorubicin@silica nanoreactor for pH-responsive delivery of an anticancer drug |
| นักวิจัย | : | Zhao, Yang , Luo, Zhong , Li, Menghuan , Qu, Qiuyu , Ma, Xing , Yu, Shu-Hong , Zhao, Yanli |
| คำค้น | : | DRNTU::Engineering::Materials::Nanostructured materials |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2558 |
| อ้างอิง | : | Zhao, Y., Luo, Z., Li, M., Qu, Q., Ma, X., Yu, S.-H., et al. (2015). A preloaded amorphous calcium carbonate/doxorubicin@silica nanoreactor for pH-responsive delivery of an anticancer drug. Angewandte chemie International edition, 54(3), 919-922. , 1433-7851 , http://hdl.handle.net/10220/25002 , http://dx.doi.org/10.1002/anie.201408510 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Angewandte chemie International edition |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | Biomedical applications of nontoxic amorphous calcium carbonate (ACC) nanoparticles have mainly been restricted because of their aqueous instability. To improve their stability in physiological environments while retaining their pH-responsiveness, a novel nanoreactor of ACC–doxorubicin (DOX)@silica was developed for drug delivery for use in cancer therapy. As a result of its rationally engineered structure, this nanoreactor maintains a low drug leakage in physiological and lysosomal/endosomal environments, and responds specifically to pH 6.5 to release the drug. This unique ACC–DOX@silica nanoreactor releases DOX precisely in the weakly acidic microenvironment of cancer cells and results in efficient cell death, thus showing its great potential as a desirable chemotherapeutic nanosystem for cancer therapy. |
| บรรณานุกรม | : |
Zhao, Yang , Luo, Zhong , Li, Menghuan , Qu, Qiuyu , Ma, Xing , Yu, Shu-Hong , Zhao, Yanli . (2558). A preloaded amorphous calcium carbonate/doxorubicin@silica nanoreactor for pH-responsive delivery of an anticancer drug.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Zhao, Yang , Luo, Zhong , Li, Menghuan , Qu, Qiuyu , Ma, Xing , Yu, Shu-Hong , Zhao, Yanli . 2558. "A preloaded amorphous calcium carbonate/doxorubicin@silica nanoreactor for pH-responsive delivery of an anticancer drug".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Zhao, Yang , Luo, Zhong , Li, Menghuan , Qu, Qiuyu , Ma, Xing , Yu, Shu-Hong , Zhao, Yanli . "A preloaded amorphous calcium carbonate/doxorubicin@silica nanoreactor for pH-responsive delivery of an anticancer drug."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2558. Print. Zhao, Yang , Luo, Zhong , Li, Menghuan , Qu, Qiuyu , Ma, Xing , Yu, Shu-Hong , Zhao, Yanli . A preloaded amorphous calcium carbonate/doxorubicin@silica nanoreactor for pH-responsive delivery of an anticancer drug. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2558.
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