| ชื่อเรื่อง | : | Asymmetric Michael addition of 5 H-oxazol-4-ones to vinyl sulfones : stereoselective synthesis of monofluorinated analogs of 2-tertiary hydroxyl-3-methyl-substituted carboxylic acidl derivatives |
| นักวิจัย | : | Liu, Qian , Qiao, Baokun , Chin, Kek Foo , Tan, Choon-Hong , Jiang, Zhiyong |
| คำค้น | : | DRNTU::Science::Chemistry::Physical chemistry::Catalysis |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2557 |
| อ้างอิง | : | Liu, Q., Qiao, B., Chin, K. F., Tan, C.-H., & Jiang, Z. (2014). Asymmetric Michael addition of 5 H-oxazol-4-ones to vinyl sulfones : stereoselective synthesis of monofluorinated analogs of 2-tertiary hydroxyl-3-methyl-substituted carboxylic acidl derivatives. Advanced synthesis & catalysis, 356(18), 3777-3783. , 1615-4150 , http://hdl.handle.net/10220/25011 , http://dx.doi.org/10.1002/adsc.201400649 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Advanced synthesis & catalysis |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | An asymmetric Michael addition of 5H-oxazol-4-ones to vinyl sulfones has been developed. In the presence of 10 mol % of quinine-based benzyl-substituted thiourea as catalyst at 0 °C, the products could be obtained with excellent enantio- and diastereoselectivity (up to>99 % ee and>20:1 dr). 1.0 mol % of catalyst also produced the corresponding adducts with similar stereoselective results when the temperature was increased to 25 °C. The obtained adducts have been demonstrated as significant synthetic fragments to conveniently access the monofluorinated analogs of biologically important 2-tertiary hydroxyl-3-methyl-substituted carboxylic acid derivatives. |
| บรรณานุกรม | : |
Liu, Qian , Qiao, Baokun , Chin, Kek Foo , Tan, Choon-Hong , Jiang, Zhiyong . (2557). Asymmetric Michael addition of 5 H-oxazol-4-ones to vinyl sulfones : stereoselective synthesis of monofluorinated analogs of 2-tertiary hydroxyl-3-methyl-substituted carboxylic acidl derivatives.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Liu, Qian , Qiao, Baokun , Chin, Kek Foo , Tan, Choon-Hong , Jiang, Zhiyong . 2557. "Asymmetric Michael addition of 5 H-oxazol-4-ones to vinyl sulfones : stereoselective synthesis of monofluorinated analogs of 2-tertiary hydroxyl-3-methyl-substituted carboxylic acidl derivatives".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Liu, Qian , Qiao, Baokun , Chin, Kek Foo , Tan, Choon-Hong , Jiang, Zhiyong . "Asymmetric Michael addition of 5 H-oxazol-4-ones to vinyl sulfones : stereoselective synthesis of monofluorinated analogs of 2-tertiary hydroxyl-3-methyl-substituted carboxylic acidl derivatives."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print. Liu, Qian , Qiao, Baokun , Chin, Kek Foo , Tan, Choon-Hong , Jiang, Zhiyong . Asymmetric Michael addition of 5 H-oxazol-4-ones to vinyl sulfones : stereoselective synthesis of monofluorinated analogs of 2-tertiary hydroxyl-3-methyl-substituted carboxylic acidl derivatives. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.
|
ridm@nrct.go.th ระบบคลังข้อมูลงานวิจัยไทย รายการโปรดที่คุณเลือกไว้
