| ชื่อเรื่อง | : | Synthesis of a natural product-like compound collection through oxidative cleavage and cyclization of linear peptides |
| นักวิจัย | : | Petersen, Rico , Le Quement, Sebastian T. , Nielsen, Thomas E. |
| คำค้น | : | DRNTU::Science::Chemistry::Organic chemistry::Oxidation |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2557 |
| อ้างอิง | : | Petersen, R., Le Quement, S. T., & Nielsen, T. E. (2014). Synthesis of a natural product-like compound collection through oxidative cleavage and cyclization of linear peptides. Angewandte chemie international edition, 53(44), 11778-11782. , 1433-7851 , http://hdl.handle.net/10220/24634 , http://dx.doi.org/10.1002/anie.201405747 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Angewandte chemie international edition |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | Massive efforts in molecular library synthesis have strived for the development of synthesis methodology which systematically delivers natural product-like compounds of high spatial complexity. Herein, we present a conceptually simple approach that builds on the power of solid-phase peptide synthesis to assemble precursor peptides (oligomers) designed to undergo oxidative cascade reactions. By harnessing the structural side-chain diversity and inherent stereochemical features offered by readily available amino acids (monomers), a proof-of-concept collection of 54 skeletally and stereochemically diverse compounds was generated, and selected compounds were elaborated into isoform-selective metalloprotease inhibitors. |
| บรรณานุกรม | : |
Petersen, Rico , Le Quement, Sebastian T. , Nielsen, Thomas E. . (2557). Synthesis of a natural product-like compound collection through oxidative cleavage and cyclization of linear peptides.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Petersen, Rico , Le Quement, Sebastian T. , Nielsen, Thomas E. . 2557. "Synthesis of a natural product-like compound collection through oxidative cleavage and cyclization of linear peptides".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Petersen, Rico , Le Quement, Sebastian T. , Nielsen, Thomas E. . "Synthesis of a natural product-like compound collection through oxidative cleavage and cyclization of linear peptides."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print. Petersen, Rico , Le Quement, Sebastian T. , Nielsen, Thomas E. . Synthesis of a natural product-like compound collection through oxidative cleavage and cyclization of linear peptides. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.
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