| ชื่อเรื่อง | : | Cobalt-catalyzed chelation-assisted alkylation of arenes with primary and secondary alkyl halides |
| นักวิจัย | : | Gao, Ke , Yamakawa, Takeshi , Yoshikai, Naohiko |
| คำค้น | : | DRNTU::Science::Chemistry::Organic chemistry |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2557 |
| อ้างอิง | : | Gao, K., Yamakawa, T., & Yoshikai, N. (2014). Cobalt-catalyzed chelation-assisted alkylation of arenes with primary and secondary alkyl halides. Synthesis, 46(15), 2024-2039. , http://hdl.handle.net/10220/24559 , http://dx.doi.org/10.1055/s-0033-1338658 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Synthesis |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | Cobalt–N-heterocyclic carbene catalytic systems have been developed for chelation-assisted ortho-alkylation of aromatic compounds with alkyl halides. Aryl imines can be selectively monoalkylated at room temperature by various primary or secondary alkyl chlorides or bromides. The catalytic system can also be applied to 2-arylpyridine derivatives, which in the absence of steric hindrance are amenable to dialkylation by an excess of the alkyl halide. Mechanistic experiments, including reactions of stereochemical probes and radical clocks, indicate that the reaction involves single-electron transfer from the cobalt center to the alkyl halide to form the corresponding alkyl radical, which has a finite lifetime before it undergoes C–C bond formation. NRF (Natl Research Foundation, S’pore) |
| บรรณานุกรม | : |
Gao, Ke , Yamakawa, Takeshi , Yoshikai, Naohiko . (2557). Cobalt-catalyzed chelation-assisted alkylation of arenes with primary and secondary alkyl halides.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Gao, Ke , Yamakawa, Takeshi , Yoshikai, Naohiko . 2557. "Cobalt-catalyzed chelation-assisted alkylation of arenes with primary and secondary alkyl halides".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Gao, Ke , Yamakawa, Takeshi , Yoshikai, Naohiko . "Cobalt-catalyzed chelation-assisted alkylation of arenes with primary and secondary alkyl halides."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print. Gao, Ke , Yamakawa, Takeshi , Yoshikai, Naohiko . Cobalt-catalyzed chelation-assisted alkylation of arenes with primary and secondary alkyl halides. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.
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