| ชื่อเรื่อง | : | Collective synthesis of 4-hydroxy-2-pyridone alkaloids and their antiproliferation activities |
| นักวิจัย | : | Ding, Feiqing , Leow, Min Li , Ma, Jimei , William, Ronny , Liao, Hongze , Liu, Xue-Wei |
| คำค้น | : | DRNTU::Science::Chemistry |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2557 |
| อ้างอิง | : | Ding, F., Leow, M. L., Ma, J., William, R., Liao, H., & Liu, X.-W. (2014). Collective synthesis of 4-hydroxy-2-pyridone alkaloids and their antiproliferation activities. Chemistry - An Asian journal, 9(9), 2548-2554. , 1861-4728 , http://hdl.handle.net/10220/20459 , http://dx.doi.org/10.1002/asia.201402466 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Chemistry - An Asian journal |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | A collective synthesis of 4-hydroxy-2-pyridone alkaloids—specifically, pretenellin B, prebassianin B, farinosone A, militarione D, pyridovericin, and torrubiellone C—has been achieved. Key steps include using a strategic convergent method to synthesize the densely substituted pyridone key intermediate by Suzuki–Miyaura cross-coupling reaction, a divergent synthesis approach of target molecules by aldol condensation of pyridone intermediate with homologous aldehydes, and an iterative synthesis of homologous aldehydes with all-trans-polyene backbones. Interestingly, among the six tumor cell lines investigated, torrubiellone C was found to induce potent and apoptotic inhibitory activities on Jurkat T cells with IC50 values of 7.05 μm. Hence, this approach could potentially contribute to the synthesis of bioactive small-molecule libraries as well as drug discovery. |
| บรรณานุกรม | : |
Ding, Feiqing , Leow, Min Li , Ma, Jimei , William, Ronny , Liao, Hongze , Liu, Xue-Wei . (2557). Collective synthesis of 4-hydroxy-2-pyridone alkaloids and their antiproliferation activities.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Ding, Feiqing , Leow, Min Li , Ma, Jimei , William, Ronny , Liao, Hongze , Liu, Xue-Wei . 2557. "Collective synthesis of 4-hydroxy-2-pyridone alkaloids and their antiproliferation activities".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Ding, Feiqing , Leow, Min Li , Ma, Jimei , William, Ronny , Liao, Hongze , Liu, Xue-Wei . "Collective synthesis of 4-hydroxy-2-pyridone alkaloids and their antiproliferation activities."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print. Ding, Feiqing , Leow, Min Li , Ma, Jimei , William, Ronny , Liao, Hongze , Liu, Xue-Wei . Collective synthesis of 4-hydroxy-2-pyridone alkaloids and their antiproliferation activities. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.
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