The advancement in strategies for bone and cartilage regeneration have been centralized on a concept that describes the close relationship between osteogenic cells, osteoconductive scaffolds, delivery growth factors and its mechanical environment. The dynamic nature of tissue repair process involves intricate mimicry of signals expressed in the biological system in response to an injury. Recently, synergistic strategies involving hybrid delivery systems that provide sequential dual delivery of biomolecules and relevant topological cues received great attention. Future advances in tissue regeneration will therefore depend on multidisciplinary strategies that encompass the crux of tissue repair aimed towards constructing the ideal functional regenerative scaffold. Here, functional scaffolds delivering therapeutics are reviewed in terms of their controlled release and healing capabilities.