| ชื่อเรื่อง | : | NHC-catalyzed ester activation : access to sterically congested spirocyclic oxindoles via reaction of α-aryl esters and unsaturated imines |
| นักวิจัย | : | Hao, Lin , Chuen, Chan Wei , Ganguly, Rakesh , Chi, Robin Yonggui |
| คำค้น | : | DRNTU::Science::Chemistry::Organic chemistry |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2556 |
| อ้างอิง | : | Hao, L., Chuen, C. W., Ganguly, R., & Chi, Y. R. (2013). NHC-Catalyzed Ester Activation: Access to Sterically Congested Spirocyclic Oxindoles via Reaction of α-Aryl Esters and Unsaturated Imines. Synlett, 24(10), 1197–1200. , 0936-5214 , http://hdl.handle.net/10220/19449 , http://dx.doi.org/10.1055/s-0033-1338945 , 173632 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Synlett |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | Carboxylic esters can be readily obtained at low cost. Therefore, asymmetric catalytic activation of esters should provide useful strategies for organic synthesis. Here we report a N-heterocyclic carbene (NHC)-mediated reaction of α-aryl acetic esters with oxindole-derived α,β-unsaturated imines. The reaction involves the formation of NHC-bound ester enolate intermediate from an ester as a key step, and furnishes spirocyclic oxindole products. The sterically congested spirocyclic oxindole bears a newly formed six-membered δ-lactams and cannot be easily prepared using other methods. |
| บรรณานุกรม | : |
Hao, Lin , Chuen, Chan Wei , Ganguly, Rakesh , Chi, Robin Yonggui . (2556). NHC-catalyzed ester activation : access to sterically congested spirocyclic oxindoles via reaction of α-aryl esters and unsaturated imines.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Hao, Lin , Chuen, Chan Wei , Ganguly, Rakesh , Chi, Robin Yonggui . 2556. "NHC-catalyzed ester activation : access to sterically congested spirocyclic oxindoles via reaction of α-aryl esters and unsaturated imines".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Hao, Lin , Chuen, Chan Wei , Ganguly, Rakesh , Chi, Robin Yonggui . "NHC-catalyzed ester activation : access to sterically congested spirocyclic oxindoles via reaction of α-aryl esters and unsaturated imines."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print. Hao, Lin , Chuen, Chan Wei , Ganguly, Rakesh , Chi, Robin Yonggui . NHC-catalyzed ester activation : access to sterically congested spirocyclic oxindoles via reaction of α-aryl esters and unsaturated imines. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.
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