| ชื่อเรื่อง | : | Photocontrolled nuclear-targeted drug delivery by single component photoresponsive fluorescent organic nanoparticles of acridin-9-methanol |
| นักวิจัย | : | Jana, Avijit , Saha, Biswajit , Banerjee, Deb Ranjan , Ghosh, Sudip Kumar , Nguyen, Kim Truc , Ma, Xing , Qu, Qiuyu , Zhao, Yanli , Pradeep Singh, N. D. |
| คำค้น | : | DRNTU::Science::Chemistry::Organic chemistry |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2556 |
| อ้างอิง | : | Jana, A., Saha, B., Banerjee, D. R., Ghosh, S. K., Nguyen, K. T., Ma, X., et al. (2013). Photocontrolled Nuclear-Targeted Drug Delivery by Single Component Photoresponsive Fluorescent Organic Nanoparticles of Acridin-9-Methanol. Bioconjugate Chemistry, 24(11), 1828–1839. , 1043-1802 , http://hdl.handle.net/10220/19434 , http://dx.doi.org/10.1021/bc400170r , 179627 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Bioconjugate chemistry |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | We report for the first time an organic nanoparticle based nuclear-targeted photoresponsive drug delivery system (DDS) for regulated anticancer drug release. Acridin-9-methanol fluorescent organic nanoparticles used in this DDS performed three important roles: (i) ″nuclear-targeted nanocarrier″ for drug delivery, (ii) ″phototrigger″ for regulated drug release, and (iii) fluorescent chromophore for cell imaging. In vitro biological studies reveal acridin-9-methanol nanoparticles of 60 nm size to be very efficient in delivering the anticancer drug chlorambucil into the target nucleus, killing the cancer cells upon irradiation. Such targeted organic nanoparticles with good biocompatibility, cellular uptake property, and efficient photoregulated drug release ability will be of great benefit in the field of targeted intracellular controlled drug release. |
| บรรณานุกรม | : |
Jana, Avijit , Saha, Biswajit , Banerjee, Deb Ranjan , Ghosh, Sudip Kumar , Nguyen, Kim Truc , Ma, Xing , Qu, Qiuyu , Zhao, Yanli , Pradeep Singh, N. D. . (2556). Photocontrolled nuclear-targeted drug delivery by single component photoresponsive fluorescent organic nanoparticles of acridin-9-methanol.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Jana, Avijit , Saha, Biswajit , Banerjee, Deb Ranjan , Ghosh, Sudip Kumar , Nguyen, Kim Truc , Ma, Xing , Qu, Qiuyu , Zhao, Yanli , Pradeep Singh, N. D. . 2556. "Photocontrolled nuclear-targeted drug delivery by single component photoresponsive fluorescent organic nanoparticles of acridin-9-methanol".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Jana, Avijit , Saha, Biswajit , Banerjee, Deb Ranjan , Ghosh, Sudip Kumar , Nguyen, Kim Truc , Ma, Xing , Qu, Qiuyu , Zhao, Yanli , Pradeep Singh, N. D. . "Photocontrolled nuclear-targeted drug delivery by single component photoresponsive fluorescent organic nanoparticles of acridin-9-methanol."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print. Jana, Avijit , Saha, Biswajit , Banerjee, Deb Ranjan , Ghosh, Sudip Kumar , Nguyen, Kim Truc , Ma, Xing , Qu, Qiuyu , Zhao, Yanli , Pradeep Singh, N. D. . Photocontrolled nuclear-targeted drug delivery by single component photoresponsive fluorescent organic nanoparticles of acridin-9-methanol. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.
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