| ชื่อเรื่อง | : | Alkene isomerization-hydroarylation tandem catalysis : indole C2-alkylation with aryl-substituted alkenes leading to 1,1-diarylalkanes |
| นักวิจัย | : | Yamakawa, Takeshi , Yoshikai, Naohiko |
| คำค้น | : | DRNTU::Science::Chemistry::Organic chemistry::Heterocyclic compounds. |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2557 |
| อ้างอิง | : | Yamakawa, T., & Yoshikai, N. (2014). Alkene isomerization-hydroarylation tandem catalysis : indole C2-alkylation with aryl-substituted alkenes leading to 1,1-diarylalkanes. Chemistry - An Asian Journal, in press. , 1861-4728 , http://hdl.handle.net/10220/19125 , http://dx.doi.org/10.1002/asia.201400135 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Chemistry - an Asian journal |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | A cobalt-N-heterocyclic carbene catalyst generated from CoBr2, imidazolium salt, and cyclohexylmagnesium bromide was found to promote the imine-directed C2-alkylation of indoles with nonconjugated arylalkenes through a tandem alkene isomerization–hydroarylation process, affording 1,1-diarylalkanes with exclusive regioselectivity. The feasibility of the tandem catalysis was demonstrated for allyl-, homoallyl-, and bishomoallylbenzene derivatives. The catalytic system is also applicable to a variety of β-substituted styrene derivatives. Mechanistic experiments using deuterium-labeled indole substrate and Grignard reagent provided insight into the cobalt-mediated C[BOND]H activation step, which likely involves exchange of the C2-hydrogen atom of the former and the β-hydrogen atoms of the latter. |
| บรรณานุกรม | : |
Yamakawa, Takeshi , Yoshikai, Naohiko . (2557). Alkene isomerization-hydroarylation tandem catalysis : indole C2-alkylation with aryl-substituted alkenes leading to 1,1-diarylalkanes.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Yamakawa, Takeshi , Yoshikai, Naohiko . 2557. "Alkene isomerization-hydroarylation tandem catalysis : indole C2-alkylation with aryl-substituted alkenes leading to 1,1-diarylalkanes".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Yamakawa, Takeshi , Yoshikai, Naohiko . "Alkene isomerization-hydroarylation tandem catalysis : indole C2-alkylation with aryl-substituted alkenes leading to 1,1-diarylalkanes."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print. Yamakawa, Takeshi , Yoshikai, Naohiko . Alkene isomerization-hydroarylation tandem catalysis : indole C2-alkylation with aryl-substituted alkenes leading to 1,1-diarylalkanes. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.
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