| ชื่อเรื่อง | : | Evaluating the toxicity of hydroxyapatite nanoparticles in catfish cells and zebrafish embryos |
| นักวิจัย | : | Zhao, Xinxin , Ong, Kimberly J. , Ede, James D. , Stafford, James L. , Ng, Kee Woei , Goss, Greg G. , Loo, Joachim Say Chye |
| คำค้น | : | DRNTU::Engineering::Materials |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2556 |
| อ้างอิง | : | Zhao, X., Ong, K. J., Ede, J. D., Stafford, J. L., Ng, K. W., Goss, G. G., et al. (2013). Evaluating the Toxicity of Hydroxyapatite Nanoparticles in Catfish Cells and Zebrafish Embryos. Small, 9(9-10), 1734-1741. , 1613-6810 , http://hdl.handle.net/10220/18981 , http://dx.doi.org/10.1002/smll.201200639 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Small |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | The toxicity of needle-(nHA-ND) and rod-shaped (nHA-RD) hydroxyapatite (HA) nanoparticles is evaluated in vitro on catfish B-cells (3B11) and catfish T-cells (28s.3) and in vivo on zebrafish embryos to determine if biological effects are similar to the effects seen in mammalian in vitro systems. Neither nHA-ND nor nHA-RD affect cell viability at concentrations of 10 to 300 μg mL−1. However, 30 μg mL−1 needle-shaped nHA lower metabolic activity of the cells. Axial deformations are seen in zebrafish exposed to 300 μg mL−1 needle shaped nHA after 120 h. For the first time, nHA is reported to cause zebrafish hatching delay. The lowest concentration (3 μg mL−1) of both types of nHA cause the highest hatching inhibition and needle-shaped nHA exposed zebrafish exhibit the lowest hatch at 72 h post fertilization. |
| บรรณานุกรม | : |
Zhao, Xinxin , Ong, Kimberly J. , Ede, James D. , Stafford, James L. , Ng, Kee Woei , Goss, Greg G. , Loo, Joachim Say Chye . (2556). Evaluating the toxicity of hydroxyapatite nanoparticles in catfish cells and zebrafish embryos.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Zhao, Xinxin , Ong, Kimberly J. , Ede, James D. , Stafford, James L. , Ng, Kee Woei , Goss, Greg G. , Loo, Joachim Say Chye . 2556. "Evaluating the toxicity of hydroxyapatite nanoparticles in catfish cells and zebrafish embryos".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Zhao, Xinxin , Ong, Kimberly J. , Ede, James D. , Stafford, James L. , Ng, Kee Woei , Goss, Greg G. , Loo, Joachim Say Chye . "Evaluating the toxicity of hydroxyapatite nanoparticles in catfish cells and zebrafish embryos."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print. Zhao, Xinxin , Ong, Kimberly J. , Ede, James D. , Stafford, James L. , Ng, Kee Woei , Goss, Greg G. , Loo, Joachim Say Chye . Evaluating the toxicity of hydroxyapatite nanoparticles in catfish cells and zebrafish embryos. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.
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