| ชื่อเรื่อง | : | Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase |
| นักวิจัย | : | Yepuri, Nageshwar Rao , Barraud, Nicolas , Mohammadi, Nasim Shah , Kardak, Bharat G. , Kjelleberg, Staffan , Rice, Scott Alan , Kelso, Michael J. |
| คำค้น | : | - |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2556 |
| อ้างอิง | : | Yepuri, N. R., Barraud, N., Mohammadi, N. S., Kardak, B. G., Kjelleberg, S., Rice, S. A., et al. (2013). Synthesis of cephalosporin-3′-diazeniumdiolates: biofilm dispersing NO-donor prodrugs activated by β-lactamase. Chemical communications, 49(42), 4791-4793. , http://hdl.handle.net/10220/17528 , http://dx.doi.org/10.1039/c3cc40869h |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Chemical communications |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | Use of biofilm dispersing NO-donor compounds in combination with antibiotics has emerged as a promising new strategy for treating drug-resistant bacterial biofilm infections. This paper details the synthesis and preliminary evaluation of six cephalosporin-3′-diazeniumdiolates as biofilm-targeted NO-donor prodrugs. Each of the compounds is shown to selectively release NO following reaction with the bacteria-specific enzyme β-lactamase and to trigger dispersion of Pseudomonas aeruginosa biofilms in vitro. |
| บรรณานุกรม | : |
Yepuri, Nageshwar Rao , Barraud, Nicolas , Mohammadi, Nasim Shah , Kardak, Bharat G. , Kjelleberg, Staffan , Rice, Scott Alan , Kelso, Michael J. . (2556). Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Yepuri, Nageshwar Rao , Barraud, Nicolas , Mohammadi, Nasim Shah , Kardak, Bharat G. , Kjelleberg, Staffan , Rice, Scott Alan , Kelso, Michael J. . 2556. "Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Yepuri, Nageshwar Rao , Barraud, Nicolas , Mohammadi, Nasim Shah , Kardak, Bharat G. , Kjelleberg, Staffan , Rice, Scott Alan , Kelso, Michael J. . "Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print. Yepuri, Nageshwar Rao , Barraud, Nicolas , Mohammadi, Nasim Shah , Kardak, Bharat G. , Kjelleberg, Staffan , Rice, Scott Alan , Kelso, Michael J. . Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.
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