| ชื่อเรื่อง | : | Characterizing the neurite outgrowth inhibitory effect of Mani |
| นักวิจัย | : | Mishra, Manisha , Lee, Sachiko , Lin, Michelle K. , Yamashita, Toshihide , Heese, Klaus |
| คำค้น | : | DRNTU::Science::Biological sciences. |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2555 |
| อ้างอิง | : | Mishra, M., Lee, S., Lin, M. K., Yamashita, T., & Heese, K. (2012). Characterizing the neurite outgrowth inhibitory effect of Mani. FEBS letters, 586(19), 3018-3023. , http://hdl.handle.net/10220/16250 , http://dx.doi.org/10.1016/j.febslet.2012.06.043 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | FEBS letters |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | Mani (myelin-associated neurite-outgrowth inhibitor) protein is implicated in both axonal guidance and axonal regeneration after central nervous system (CNS) injury. Here, we applied a neurite outgrowth assay, coupled with a siRNA-driven investigation and immunocytochemistry, to unveil Mani’s axonal outgrowth inhibitory effect in embryonic rat cortical primary neurons in vitro. We further demonstrate Mani’s neuronal localization in comparison with a principal subunit, Cdc27, of the anaphase promoting complex (APC). Considering the protein structure of Mani obtained via a series of bio-computational studies, we propose a Cdc27-Mani-APC-related signalling pathway may be involved in CNS axon regeneration. |
| บรรณานุกรม | : |
Mishra, Manisha , Lee, Sachiko , Lin, Michelle K. , Yamashita, Toshihide , Heese, Klaus . (2555). Characterizing the neurite outgrowth inhibitory effect of Mani.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Mishra, Manisha , Lee, Sachiko , Lin, Michelle K. , Yamashita, Toshihide , Heese, Klaus . 2555. "Characterizing the neurite outgrowth inhibitory effect of Mani".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Mishra, Manisha , Lee, Sachiko , Lin, Michelle K. , Yamashita, Toshihide , Heese, Klaus . "Characterizing the neurite outgrowth inhibitory effect of Mani."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print. Mishra, Manisha , Lee, Sachiko , Lin, Michelle K. , Yamashita, Toshihide , Heese, Klaus . Characterizing the neurite outgrowth inhibitory effect of Mani. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.
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