| ชื่อเรื่อง | : | Effects of F’, F-ANA and LNA modification on the stability of DNA G-quadruplex |
| นักวิจัย | : | Li, Zhe |
| คำค้น | : | - |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2556 |
| อ้างอิง | : | Li, Z. (2013, March). Effects of F’, F-ANA and LNA Modification on the Stability of DNA G-quadruplex. Presented at Discover URECA @ NTU poster exhibition and competition, Nanyang Technological University, Singapore. , http://hdl.handle.net/10220/11316 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | - |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | Quadruplex is formed by G-tetrads (Fig. a) stacking and it forms at Guanine-rich region. G-quadruplex is reported to have anti-cancer and anti-HIV effect [1]. T0 quadruplex (Fig. b) studied in this project is in (4+0) conformation and has very high symmetry [2]. F’, F-ANA and LNA (Fig. d-f) are modified sugars and they are highly stable in biological condition, easy to synthesize and soluble in water. Thanks to these beneficial properties, F’, F-ANA and LNA are promising candidates for DNA and RNA based drug design [3-5]. In this project, The effects of F’, F-ANA and LNA modifications on thermal stability of G-quadruplex were studied on the platform of T0 G-quadruplex and characterized by UV melting. [1st Awards] |
| บรรณานุกรม | : |
Li, Zhe . (2556). Effects of F’, F-ANA and LNA modification on the stability of DNA G-quadruplex.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Li, Zhe . 2556. "Effects of F’, F-ANA and LNA modification on the stability of DNA G-quadruplex".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Li, Zhe . "Effects of F’, F-ANA and LNA modification on the stability of DNA G-quadruplex."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print. Li, Zhe . Effects of F’, F-ANA and LNA modification on the stability of DNA G-quadruplex. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.
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