| ชื่อเรื่อง | : | Stability of the β-structure in prion protein : a molecular dynamics study based on polarized force field |
| นักวิจัย | : | Xu, Zhijun , Lazim, Raudah , Mei, Ye , Zhang, Dawei |
| คำค้น | : | - |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2555 |
| อ้างอิง | : | Xu, Z., Lazim, R., Mei, Y., & Zhang, D. (2012). Stability of the β-structure in prion protein: A molecular dynamics study based on polarized force field. Chemical Physics Letters, 539-540, 239-244. , 0009-2614 , http://hdl.handle.net/10220/10796 , http://dx.doi.org/10.1016/j.cplett.2012.05.025 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Chemical physics letters |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | Conformational changes of the antiparallel β-sheet in normal cellular prion protein (PrPC) of rat, bovine, and human are investigated by molecular dynamics simulations in both neutral and acidic environment. Using a recently developed simulation method based on an on-the-fly polarized protein-specific charge (PPC) update scheme during the simulation process, we evaluate and compare the cross-species performances of the β-sheet during the early stage transition from the PrPC to its mutant configuration. Through this study, we observe the growth of the β-sheet structure in all species studied with the extent of elongation in β-sheet being different across the three species. |
| บรรณานุกรม | : |
Xu, Zhijun , Lazim, Raudah , Mei, Ye , Zhang, Dawei . (2555). Stability of the β-structure in prion protein : a molecular dynamics study based on polarized force field.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Xu, Zhijun , Lazim, Raudah , Mei, Ye , Zhang, Dawei . 2555. "Stability of the β-structure in prion protein : a molecular dynamics study based on polarized force field".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Xu, Zhijun , Lazim, Raudah , Mei, Ye , Zhang, Dawei . "Stability of the β-structure in prion protein : a molecular dynamics study based on polarized force field."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print. Xu, Zhijun , Lazim, Raudah , Mei, Ye , Zhang, Dawei . Stability of the β-structure in prion protein : a molecular dynamics study based on polarized force field. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.
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