Advanced drug discovery techniques have led to identifications of complex chemical compounds with excellent therapeutic potentials. However, many of these compounds exhibit poor aqueous solubility1 and lead to incomplete, erratic and slow systemic absorption. To enhance drug solubility as well as bioavailability, formulating the active pharmaceutical ingredients (API) into nano-particles (NPs) has been proven to be simple and effective2. To improve flow properties and compaction characteristics within further tablets and capsules manufacturing process (Figure 1), nano-API are adsorbed onto the agglomeration templates to produce hierarchically-ordered micro-granules of the NPs. Many of current nano-API production and micro-granulation techniques, however, possess low energy and mass efficiency due to the harsh operating conditions3. A more sustainable manufacturing process of nano-API and micro-granules operated at ambient temperature, pressure, neutral pH, and absent of organic solvent, is studied in this project. [1st Awards]