| ชื่อเรื่อง | : | Molecular mimicry-based repositioning of Nutlin-3 to anti-apoptotic Bcl-2 family proteins |
| นักวิจัย | : | Ha, Ji-Hyang , Won, Eun-Young , Shin, Jae-Sun , Jang, Mi , Ryu, Kyoung-Seok , Baek, Kwanghee , Park, Sung Goo , Park, Byoung Chul , Yoon, Ho Sup , Chi, Seung-Wook |
| คำค้น | : | DRNTU::Science::Biological sciences. |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2554 |
| อ้างอิง | : | Ha, J. H., Won, E. Y., Shin, J. S., Jang, M., Ryu, K. S., Baek, K., et al. (2011). Molecular mimicry-based repositioning of Nutlin-3 to anti-apoptotic Bcl-2 family proteins. Journal of the American chemical society, 133(5), 1244-1247. , http://hdl.handle.net/10220/8736 , http://dx.doi.org/10.1021/ja109521f |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Journal of the American chemical society |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | The identification of off-target binding of drugs is a key to repositioning drugs to new therapeutic categories. Here we show the universal interactions of the p53 transactivation domain (p53TAD) with various antiapoptotic Bcl-2 family proteins via a mouse double minute 2 (MDM2) binding motif, which play an important role in transcription-independent apoptotic pathways of p53. Interestingly, our structural studies reveal that the anti-apoptotic Bcl-2 family proteins and MDM2 share a similar mode of interaction with the p53TAD. On the basis of this close molecular mimicry, our NMR results demonstrate that the potent MDM2 antagonists Nutlin-3 and PMI bind to the anti-apoptotic Bcl-2 family proteins in a manner analogous to that with the p53TAD. |
| บรรณานุกรม | : |
Ha, Ji-Hyang , Won, Eun-Young , Shin, Jae-Sun , Jang, Mi , Ryu, Kyoung-Seok , Baek, Kwanghee , Park, Sung Goo , Park, Byoung Chul , Yoon, Ho Sup , Chi, Seung-Wook . (2554). Molecular mimicry-based repositioning of Nutlin-3 to anti-apoptotic Bcl-2 family proteins.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Ha, Ji-Hyang , Won, Eun-Young , Shin, Jae-Sun , Jang, Mi , Ryu, Kyoung-Seok , Baek, Kwanghee , Park, Sung Goo , Park, Byoung Chul , Yoon, Ho Sup , Chi, Seung-Wook . 2554. "Molecular mimicry-based repositioning of Nutlin-3 to anti-apoptotic Bcl-2 family proteins".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Ha, Ji-Hyang , Won, Eun-Young , Shin, Jae-Sun , Jang, Mi , Ryu, Kyoung-Seok , Baek, Kwanghee , Park, Sung Goo , Park, Byoung Chul , Yoon, Ho Sup , Chi, Seung-Wook . "Molecular mimicry-based repositioning of Nutlin-3 to anti-apoptotic Bcl-2 family proteins."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2554. Print. Ha, Ji-Hyang , Won, Eun-Young , Shin, Jae-Sun , Jang, Mi , Ryu, Kyoung-Seok , Baek, Kwanghee , Park, Sung Goo , Park, Byoung Chul , Yoon, Ho Sup , Chi, Seung-Wook . Molecular mimicry-based repositioning of Nutlin-3 to anti-apoptotic Bcl-2 family proteins. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2554.
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