| ชื่อเรื่อง | : | Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells |
| นักวิจัย | : | Choi, Bo-Hwa , Kim, Wanil , Wang, Qiuxia Chelsia , Kim, Dong-Chan , Tan, Swee Ngin , Yong, Jean Wan Hong , Kim, Kyong-Tai , Yoon, Ho Sup |
| คำค้น | : | DRNTU::Science::Biological sciences. |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2550 |
| อ้างอิง | : | Choi, B. -H., Kim, W., Wang, Q. C., Kim, D., -C., Tan, S., N., Yong, J. W. H., et al. (2008). Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells. Cancer Letters, 261(1), 37-45. , http://hdl.handle.net/10220/8384 , http://dx.doi.org/10.1016/j.canlet.2007.11.014 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Cancer letters |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | Here, we demonstrate that kinetin riboside (KR), a cytokinin analog, induces apoptosis in HeLa and mouse melanoma B16F-10 cells. KR disrupted the mitochondrial membrane potential and induced the release of cytochrome c and activation of caspase-3. Bad were upregulated while Bcl-2 was down-regulated under KR exposure. A tumor growth in mice was dramatically suppressed by KR. In contrast, human skin fibroblast CCL-116 and bovine primary fibroblast cells show resistances to KR and no significant changes in Bad, Bcl-XL, and cleaved PARP were observed. Our data suggest that KR selectively induces apoptosis in cancer cells through the classical mitochondria dependent apoptosis pathway. |
| บรรณานุกรม | : |
Choi, Bo-Hwa , Kim, Wanil , Wang, Qiuxia Chelsia , Kim, Dong-Chan , Tan, Swee Ngin , Yong, Jean Wan Hong , Kim, Kyong-Tai , Yoon, Ho Sup . (2550). Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Choi, Bo-Hwa , Kim, Wanil , Wang, Qiuxia Chelsia , Kim, Dong-Chan , Tan, Swee Ngin , Yong, Jean Wan Hong , Kim, Kyong-Tai , Yoon, Ho Sup . 2550. "Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Choi, Bo-Hwa , Kim, Wanil , Wang, Qiuxia Chelsia , Kim, Dong-Chan , Tan, Swee Ngin , Yong, Jean Wan Hong , Kim, Kyong-Tai , Yoon, Ho Sup . "Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2550. Print. Choi, Bo-Hwa , Kim, Wanil , Wang, Qiuxia Chelsia , Kim, Dong-Chan , Tan, Swee Ngin , Yong, Jean Wan Hong , Kim, Kyong-Tai , Yoon, Ho Sup . Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2550.
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