| ชื่อเรื่อง | : | Structure of Bcl-xL-Bak peptide complex : recognition between regulators of Apoptosis |
| นักวิจัย | : | Sattler, Michael , Liang, Heng , Nettesheim, David G. , Meadows, Robert P. , Harlan, John E. , Eberstadt, Matthias , Yoon, Ho Sup , Shuker, Suzanne B. , Chang, Brian S. , Minn, Andy J. , Thompson, Craig B. , Fesik, Stephen W. |
| คำค้น | : | DRNTU::Business::Public relations::Crisis communication. |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2540 |
| อ้างอิง | : | Sattler, M., Liang, H., Nettesheim, D., Meadows, Robert P., Harlan, John E., Eberstadt, M., et al. (1997). Structure of Bcl-xL-Bak Peptide Complex: Recognition Between Regulators of Apoptosis. Science, 275, 983-986. , http://hdl.handle.net/10220/7619 , http://dx.doi.org/10.1126/science.275.5302.983 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Science |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | Heterodimerization between members of the Bcl-2 family of proteins is a key event in the regulation of programmed cell death. The molecular basis for heterodimer formation was investigated by determination of the solution structure of a complex between the survival protein Bcl-xL and the death-promoting region of the Bcl-2–related protein Bak. The structure and binding affinities of mutant Bak peptides indicate that the Bak peptide adopts an amphipathic α helix that interacts with Bcl-xL through hydrophobic and electrostatic interactions. Mutations in full-length Bak that disrupt either type of interaction inhibit the ability of Bak to heterodimerize with Bcl-xL. |
| บรรณานุกรม | : |
Sattler, Michael , Liang, Heng , Nettesheim, David G. , Meadows, Robert P. , Harlan, John E. , Eberstadt, Matthias , Yoon, Ho Sup , Shuker, Suzanne B. , Chang, Brian S. , Minn, Andy J. , Thompson, Craig B. , Fesik, Stephen W. . (2540). Structure of Bcl-xL-Bak peptide complex : recognition between regulators of Apoptosis.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Sattler, Michael , Liang, Heng , Nettesheim, David G. , Meadows, Robert P. , Harlan, John E. , Eberstadt, Matthias , Yoon, Ho Sup , Shuker, Suzanne B. , Chang, Brian S. , Minn, Andy J. , Thompson, Craig B. , Fesik, Stephen W. . 2540. "Structure of Bcl-xL-Bak peptide complex : recognition between regulators of Apoptosis".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Sattler, Michael , Liang, Heng , Nettesheim, David G. , Meadows, Robert P. , Harlan, John E. , Eberstadt, Matthias , Yoon, Ho Sup , Shuker, Suzanne B. , Chang, Brian S. , Minn, Andy J. , Thompson, Craig B. , Fesik, Stephen W. . "Structure of Bcl-xL-Bak peptide complex : recognition between regulators of Apoptosis."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2540. Print. Sattler, Michael , Liang, Heng , Nettesheim, David G. , Meadows, Robert P. , Harlan, John E. , Eberstadt, Matthias , Yoon, Ho Sup , Shuker, Suzanne B. , Chang, Brian S. , Minn, Andy J. , Thompson, Craig B. , Fesik, Stephen W. . Structure of Bcl-xL-Bak peptide complex : recognition between regulators of Apoptosis. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2540.
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