A micellar liquid chromatography (MLC) procedure was developed for the simultaneous separation and determination of lidocaine hydrochloride (LD HCl) and tolperisone hydrochloride (TP HCl) using a short-column C18 (12.5 mm×4.6 mm, 5 μm), sodium dodecyl sulfate (SDS) with a small amount of isopropanol, and diode array detector. The optimum conditions for the simultaneous determination of both drugs were 0.075 mol l-1 SDS-7.5% (v/v) isopropanol with a flow rate of 0.7 ml min-1 and detection at 210 nm. The LOD (2S/N) of LD HCl was 0.73 ng 20 μl-1, whereas that of TP HCl was 1.43 ng 20 μl-1. The calibration curves for LD HCl and TP HCl were linear over the ranges 0.125-500 μg ml-1 (r2=0.9999) and 1.00-500 μg ml-1 (r2=0.9997), respectively. The %recoveries of both drugs were in the range 98-103% and the %RSD values were less than 2. The proposed method has been successfully applied to the simultaneous determination of TP HCl and LD HCl in various pharmaceutical preparations.