Thesis (M.Sc.)--Chulalongkorn University, 2007

Objective: To compare the effectiveness of 2-octylcyanoacrylate and absorbable subcuticular suture for surgical incision wound closure. Study designs: Randomized controlled trial and economic analysis. Setting: Minor Operative room and outpatient surgical clinic, Department of Surgery, Bangkok Metropolitan Administration Medical College and Vajira hospital. Research Methodology: 88 patients, who indicated for surgical removal of benign skin or subcutaneous lesion, were computed randomly assigned into two groups: 2-octylcyanoacrylate for wound closure (N = 44) and absorbable subcuticular suture for wound closure (N = 44). The wound score was used for evaluation in 7th day postoperative by independent professional observers. The cost-effectiveness analysis also performed alongside with trial. Results: 2-octylcyanoacrylate had wound closure evaluation score, wound approximation (9.93 ± 0.34 VS 8.98 ± 2.35, p = 0.002, 95% CI 0.22-1.68), wound inflammation (9.86 ± 0.35 VS 8.33 ± 2.47, p < 0.001, 95% CI 0.76-2.29), wound epithelization (9.83 ± 0.44 VS 8.76 ± 2.48, p = 0.018, 95% CI 0.30-1.84), wound closure time (104.09 ± 14.40 VS 227.33 ± 39.16, p < 0.001, 95% CI 111.30-136.43) better than absorbable subcuticular suture with statistically significant. The 2-octylcyanoacrylate had better cost-effectiveness analysis than absorbable subcuticular suture. Conclusion: 2-octylcyanoacrylate is effectiveness for surgical incision wound closure comparing with absorbable subcuticular suture.